Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice

Hepatic apoptosis is involved in the progression of alcoholic liver disease (ALD). Caspase-8, the apical initiator in death receptor-mediated apoptosis, has been implicated in acute liver injury and in non-alcoholic steatohepatitis. However, the relevance of Caspase-8 in the pathogenesis of ALD rema...

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Detalles Bibliográficos
Autores principales: Hao, Fengjie, Cubero, Francisco Javier, Ramadori, Pierluigi, Liao, Lijun, Haas, Ute, Lambertz, Daniela, Sonntag, Roland, Bangen, Jörg- Martin, Gassler, Nikolaus, Hoss, Mareike, Streetz, Konrad L, Reissing, Johanna, Zimmermann, Henning W, Trautwein, Christian, Liedtke, Christian, Nevzorova, Yulia A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680911/
https://www.ncbi.nlm.nih.gov/pubmed/29072704
http://dx.doi.org/10.1038/cddis.2017.532

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