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Oxidative Stress in Stem Cell Aging
Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nuclei...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680960/ https://www.ncbi.nlm.nih.gov/pubmed/29113471 http://dx.doi.org/10.1177/0963689717735407 |
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author | Chen, Feng Liu, Yingxia Wong, Nai-Kei Xiao, Jia So, Kwok-Fai |
author_facet | Chen, Feng Liu, Yingxia Wong, Nai-Kei Xiao, Jia So, Kwok-Fai |
author_sort | Chen, Feng |
collection | PubMed |
description | Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nucleic acids, proteins, lipids, and carbohydrates have been recognized to contribute to stem cell aging. Excessive production of reactive oxygen species and insufficient cellular antioxidant reserves compromise cell repair and metabolic homeostasis, which serves as a mechanistic switch for a variety of aging-related pathways. Understanding the molecular trigger, regulation, and outcomes of those signaling networks is critical for developing novel therapies for aging-related diseases by targeting stem cell aging. Here we explore the key features of stem cell aging biology, with an emphasis on the roles of oxidative stress in the aging process at the molecular level. As a concept of cytoprotection of stem cells in transplantation, we also discuss how systematic enhancement of endogenous antioxidant capacity before or during graft into tissues can potentially raise the efficacy of clinical therapy. Finally, future directions for elucidating the control of oxidative stress and developing preventive/curative strategies against stem cell aging are discussed. |
format | Online Article Text |
id | pubmed-5680960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-56809602017-11-21 Oxidative Stress in Stem Cell Aging Chen, Feng Liu, Yingxia Wong, Nai-Kei Xiao, Jia So, Kwok-Fai Cell Transplant Original Articles Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nucleic acids, proteins, lipids, and carbohydrates have been recognized to contribute to stem cell aging. Excessive production of reactive oxygen species and insufficient cellular antioxidant reserves compromise cell repair and metabolic homeostasis, which serves as a mechanistic switch for a variety of aging-related pathways. Understanding the molecular trigger, regulation, and outcomes of those signaling networks is critical for developing novel therapies for aging-related diseases by targeting stem cell aging. Here we explore the key features of stem cell aging biology, with an emphasis on the roles of oxidative stress in the aging process at the molecular level. As a concept of cytoprotection of stem cells in transplantation, we also discuss how systematic enhancement of endogenous antioxidant capacity before or during graft into tissues can potentially raise the efficacy of clinical therapy. Finally, future directions for elucidating the control of oxidative stress and developing preventive/curative strategies against stem cell aging are discussed. SAGE Publications 2017-11-08 2017-09 /pmc/articles/PMC5680960/ /pubmed/29113471 http://dx.doi.org/10.1177/0963689717735407 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Chen, Feng Liu, Yingxia Wong, Nai-Kei Xiao, Jia So, Kwok-Fai Oxidative Stress in Stem Cell Aging |
title | Oxidative Stress in Stem Cell Aging |
title_full | Oxidative Stress in Stem Cell Aging |
title_fullStr | Oxidative Stress in Stem Cell Aging |
title_full_unstemmed | Oxidative Stress in Stem Cell Aging |
title_short | Oxidative Stress in Stem Cell Aging |
title_sort | oxidative stress in stem cell aging |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680960/ https://www.ncbi.nlm.nih.gov/pubmed/29113471 http://dx.doi.org/10.1177/0963689717735407 |
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