Cargando…

Vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites

The study discusses the synthesis of polymer-silica composites comprising water soluble drug (ibuprofen sodium, IBS). The polymers selected for this study were poly(TRIM) and poly(HEMA-co-TRIM) produced in the form of permanently porous beads via the suspension-emulsion polymerization method. The ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Kierys, Agnieszka, Krasucka, Patrycja, Grochowicz, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681307/
https://www.ncbi.nlm.nih.gov/pubmed/29158703
http://dx.doi.org/10.1016/j.jsps.2017.03.004
_version_ 1783277894680707072
author Kierys, Agnieszka
Krasucka, Patrycja
Grochowicz, Marta
author_facet Kierys, Agnieszka
Krasucka, Patrycja
Grochowicz, Marta
author_sort Kierys, Agnieszka
collection PubMed
description The study discusses the synthesis of polymer-silica composites comprising water soluble drug (ibuprofen sodium, IBS). The polymers selected for this study were poly(TRIM) and poly(HEMA-co-TRIM) produced in the form of permanently porous beads via the suspension-emulsion polymerization method. The acid and base set ternary composites were prepared by the saturation of the solid dispersions of drug (poly(TRIM)-IBS and/or poly(HEMA-co-TRIM)-IBS) with TEOS, and followed by their exposition to the vapour mixture of water and ammonia, or water and hydrochloric acid, at autogenous pressure. The conducted analyses reveal that the internal structure and total porosity of the resulting composites strongly depend on the catalyst which was used for silica precursor gelation. The parameters characterizing the porosity of both of the acid set composites are much lower than the parameters of the base set composites. Moreover, the basic catalyst supplied in the vapour phase does not affect the ibuprofen sodium molecules, whereas the acid one causes transformation of the ibuprofen sodium into the sodium chloride and a derivative of propanoic acid, which is poorly water soluble. The release profiles of ibuprofen sodium from composites demonstrate that there are differences in the rate and efficiency of drug desorption from them. They are mainly affected by the chemical character of the polymeric carrier but are also associated with the restricted swelling of the composites in the buffer solution after precipitation of silica gel.
format Online
Article
Text
id pubmed-5681307
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-56813072017-11-20 Vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites Kierys, Agnieszka Krasucka, Patrycja Grochowicz, Marta Saudi Pharm J Article The study discusses the synthesis of polymer-silica composites comprising water soluble drug (ibuprofen sodium, IBS). The polymers selected for this study were poly(TRIM) and poly(HEMA-co-TRIM) produced in the form of permanently porous beads via the suspension-emulsion polymerization method. The acid and base set ternary composites were prepared by the saturation of the solid dispersions of drug (poly(TRIM)-IBS and/or poly(HEMA-co-TRIM)-IBS) with TEOS, and followed by their exposition to the vapour mixture of water and ammonia, or water and hydrochloric acid, at autogenous pressure. The conducted analyses reveal that the internal structure and total porosity of the resulting composites strongly depend on the catalyst which was used for silica precursor gelation. The parameters characterizing the porosity of both of the acid set composites are much lower than the parameters of the base set composites. Moreover, the basic catalyst supplied in the vapour phase does not affect the ibuprofen sodium molecules, whereas the acid one causes transformation of the ibuprofen sodium into the sodium chloride and a derivative of propanoic acid, which is poorly water soluble. The release profiles of ibuprofen sodium from composites demonstrate that there are differences in the rate and efficiency of drug desorption from them. They are mainly affected by the chemical character of the polymeric carrier but are also associated with the restricted swelling of the composites in the buffer solution after precipitation of silica gel. Elsevier 2017-11 2017-03-20 /pmc/articles/PMC5681307/ /pubmed/29158703 http://dx.doi.org/10.1016/j.jsps.2017.03.004 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kierys, Agnieszka
Krasucka, Patrycja
Grochowicz, Marta
Vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites
title Vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites
title_full Vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites
title_fullStr Vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites
title_full_unstemmed Vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites
title_short Vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites
title_sort vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681307/
https://www.ncbi.nlm.nih.gov/pubmed/29158703
http://dx.doi.org/10.1016/j.jsps.2017.03.004
work_keys_str_mv AT kierysagnieszka vapourphasemethodinthesynthesisofpolymeribuprofensodiumsilicagelcomposites
AT krasuckapatrycja vapourphasemethodinthesynthesisofpolymeribuprofensodiumsilicagelcomposites
AT grochowiczmarta vapourphasemethodinthesynthesisofpolymeribuprofensodiumsilicagelcomposites