Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity

A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced p...

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Autores principales: Awaad, Amani S., Alafeefy, Ahmed M., Alasmary, Fatmah A.S., El-Meligy, Reham M., Zain, M.E., Alqasoumi, Saleh I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681326/
https://www.ncbi.nlm.nih.gov/pubmed/29158702
http://dx.doi.org/10.1016/j.jsps.2017.02.012
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author Awaad, Amani S.
Alafeefy, Ahmed M.
Alasmary, Fatmah A.S.
El-Meligy, Reham M.
Zain, M.E.
Alqasoumi, Saleh I.
author_facet Awaad, Amani S.
Alafeefy, Ahmed M.
Alasmary, Fatmah A.S.
El-Meligy, Reham M.
Zain, M.E.
Alqasoumi, Saleh I.
author_sort Awaad, Amani S.
collection PubMed
description A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging.
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spelling pubmed-56813262017-11-20 Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity Awaad, Amani S. Alafeefy, Ahmed M. Alasmary, Fatmah A.S. El-Meligy, Reham M. Zain, M.E. Alqasoumi, Saleh I. Saudi Pharm J Article A novel and safe essential amino acid (Leucine) incorporating sulfanilamide was synthesized, and evaluated for its anti-ulcerogenic activity and in vitro anti-Helicobacter pylori activity. The new molecule showed a dose dependent activity against absolute ethanol-induced ulcer in rats, it produced percent protection of control ulcer by 66.7 at dose 100 mg/kg. In addition it showed a potent anti-Helicobacter pylori activity in vitro against 7 clinically isolated strains. The minimum inhibitory concentration (MIC) ranged from 12.5 to 50 μg/ml. The preliminary safety studies and toxicity profile are optimistic and encouraging. Elsevier 2017-11 2017-02-27 /pmc/articles/PMC5681326/ /pubmed/29158702 http://dx.doi.org/10.1016/j.jsps.2017.02.012 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Awaad, Amani S.
Alafeefy, Ahmed M.
Alasmary, Fatmah A.S.
El-Meligy, Reham M.
Zain, M.E.
Alqasoumi, Saleh I.
Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_full Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_fullStr Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_full_unstemmed Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_short Novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
title_sort novel essential amino acid-sulfanilamide hybrid as safe anti-ulcerogenic agent with anti-helicobacter pylori activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681326/
https://www.ncbi.nlm.nih.gov/pubmed/29158702
http://dx.doi.org/10.1016/j.jsps.2017.02.012
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