KDM6B modulates MAPK pathway mediating multiple myeloma cell growth and survival

Recent studies have delineated cancer type-specific roles of histone 3 lysine 27 (H3K27) demethylase KDM6B/JMJD3 depending on its H3K27 demethylase activity. Here we show that KDM6B is expressed in multiple myeloma (MM); and that shRNA-mediated knockdown and CRISPR-mediated knockout of KDM6B abrogat...

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Detalles Bibliográficos
Autores principales: Ohguchi, Hiroto, Harada, Takeshi, Sagawa, Morihiko, Kikuchi, Shohei, Tai, Yu-Tzu, Richardson, Paul G., Hideshima, Teru, Anderson, Kenneth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681448/
https://www.ncbi.nlm.nih.gov/pubmed/28487543
http://dx.doi.org/10.1038/leu.2017.141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681448/
https://www.ncbi.nlm.nih.gov/pubmed/28487543
http://dx.doi.org/10.1038/leu.2017.141

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