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Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients
Familial Parkinson's disease (PD) is often caused by mutation of a certain gene, while sporadic PD is associated with variants of genes which can influence the susceptibility to PD. The goal of this study was to investigate the difference between the two forms of PD in terms of brain abnormalit...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681528/ https://www.ncbi.nlm.nih.gov/pubmed/29163072 http://dx.doi.org/10.3389/fnana.2017.00099 |
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author | Tang, Yan Xiao, Xue Xie, Hua Wan, Chang-min Meng, Li Liu, Zhen-hua Liao, Wei-hua Tang, Bei-sha Guo, Ji-feng |
author_facet | Tang, Yan Xiao, Xue Xie, Hua Wan, Chang-min Meng, Li Liu, Zhen-hua Liao, Wei-hua Tang, Bei-sha Guo, Ji-feng |
author_sort | Tang, Yan |
collection | PubMed |
description | Familial Parkinson's disease (PD) is often caused by mutation of a certain gene, while sporadic PD is associated with variants of genes which can influence the susceptibility to PD. The goal of this study was to investigate the difference between the two forms of PD in terms of brain abnormalities using resting-state functional MRI and graph theory. Thirty-one familial PD patients and 36 sporadic PD patients underwent resting-state functional MRI scanning. Frequency-dependent functional connectivity was calculated for each subject using wavelet-based correlations of BOLD signal over 246 brain regions from Brainnetome Atlas. Graph theoretical analysis was then performed to analyze the topology of the functional network, and functional connectome differences were identified with a network-based statistical approach. Our results revealed a frequency-specific (0.016 and 0.031 Hz) connectome difference between familial and sporadic forms of PD, as indicated by an increase in assortativity and decrease in the nodal strength in the left medial amygdala of the familial PD group. In addition, the familial PD patients also showed a distinctive functional network between the left medial amygdala and regions related to retrieval of motion information. The present study indicates that the medial amygdala might be most vulnerable to both sporadic and familial PD. Our findings provide some new insights into disrupted resting-state functional connectomes between sporadic PD and familial PD. |
format | Online Article Text |
id | pubmed-5681528 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-56815282017-11-21 Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients Tang, Yan Xiao, Xue Xie, Hua Wan, Chang-min Meng, Li Liu, Zhen-hua Liao, Wei-hua Tang, Bei-sha Guo, Ji-feng Front Neuroanat Neuroscience Familial Parkinson's disease (PD) is often caused by mutation of a certain gene, while sporadic PD is associated with variants of genes which can influence the susceptibility to PD. The goal of this study was to investigate the difference between the two forms of PD in terms of brain abnormalities using resting-state functional MRI and graph theory. Thirty-one familial PD patients and 36 sporadic PD patients underwent resting-state functional MRI scanning. Frequency-dependent functional connectivity was calculated for each subject using wavelet-based correlations of BOLD signal over 246 brain regions from Brainnetome Atlas. Graph theoretical analysis was then performed to analyze the topology of the functional network, and functional connectome differences were identified with a network-based statistical approach. Our results revealed a frequency-specific (0.016 and 0.031 Hz) connectome difference between familial and sporadic forms of PD, as indicated by an increase in assortativity and decrease in the nodal strength in the left medial amygdala of the familial PD group. In addition, the familial PD patients also showed a distinctive functional network between the left medial amygdala and regions related to retrieval of motion information. The present study indicates that the medial amygdala might be most vulnerable to both sporadic and familial PD. Our findings provide some new insights into disrupted resting-state functional connectomes between sporadic PD and familial PD. Frontiers Media S.A. 2017-11-06 /pmc/articles/PMC5681528/ /pubmed/29163072 http://dx.doi.org/10.3389/fnana.2017.00099 Text en Copyright © 2017 Tang, Xiao, Xie, Wan, Meng, Liu, Liao, Tang and Guo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Tang, Yan Xiao, Xue Xie, Hua Wan, Chang-min Meng, Li Liu, Zhen-hua Liao, Wei-hua Tang, Bei-sha Guo, Ji-feng Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients |
title | Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients |
title_full | Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients |
title_fullStr | Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients |
title_full_unstemmed | Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients |
title_short | Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients |
title_sort | altered functional brain connectomes between sporadic and familial parkinson's patients |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681528/ https://www.ncbi.nlm.nih.gov/pubmed/29163072 http://dx.doi.org/10.3389/fnana.2017.00099 |
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