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Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients

Familial Parkinson's disease (PD) is often caused by mutation of a certain gene, while sporadic PD is associated with variants of genes which can influence the susceptibility to PD. The goal of this study was to investigate the difference between the two forms of PD in terms of brain abnormalit...

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Autores principales: Tang, Yan, Xiao, Xue, Xie, Hua, Wan, Chang-min, Meng, Li, Liu, Zhen-hua, Liao, Wei-hua, Tang, Bei-sha, Guo, Ji-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681528/
https://www.ncbi.nlm.nih.gov/pubmed/29163072
http://dx.doi.org/10.3389/fnana.2017.00099
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author Tang, Yan
Xiao, Xue
Xie, Hua
Wan, Chang-min
Meng, Li
Liu, Zhen-hua
Liao, Wei-hua
Tang, Bei-sha
Guo, Ji-feng
author_facet Tang, Yan
Xiao, Xue
Xie, Hua
Wan, Chang-min
Meng, Li
Liu, Zhen-hua
Liao, Wei-hua
Tang, Bei-sha
Guo, Ji-feng
author_sort Tang, Yan
collection PubMed
description Familial Parkinson's disease (PD) is often caused by mutation of a certain gene, while sporadic PD is associated with variants of genes which can influence the susceptibility to PD. The goal of this study was to investigate the difference between the two forms of PD in terms of brain abnormalities using resting-state functional MRI and graph theory. Thirty-one familial PD patients and 36 sporadic PD patients underwent resting-state functional MRI scanning. Frequency-dependent functional connectivity was calculated for each subject using wavelet-based correlations of BOLD signal over 246 brain regions from Brainnetome Atlas. Graph theoretical analysis was then performed to analyze the topology of the functional network, and functional connectome differences were identified with a network-based statistical approach. Our results revealed a frequency-specific (0.016 and 0.031 Hz) connectome difference between familial and sporadic forms of PD, as indicated by an increase in assortativity and decrease in the nodal strength in the left medial amygdala of the familial PD group. In addition, the familial PD patients also showed a distinctive functional network between the left medial amygdala and regions related to retrieval of motion information. The present study indicates that the medial amygdala might be most vulnerable to both sporadic and familial PD. Our findings provide some new insights into disrupted resting-state functional connectomes between sporadic PD and familial PD.
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spelling pubmed-56815282017-11-21 Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients Tang, Yan Xiao, Xue Xie, Hua Wan, Chang-min Meng, Li Liu, Zhen-hua Liao, Wei-hua Tang, Bei-sha Guo, Ji-feng Front Neuroanat Neuroscience Familial Parkinson's disease (PD) is often caused by mutation of a certain gene, while sporadic PD is associated with variants of genes which can influence the susceptibility to PD. The goal of this study was to investigate the difference between the two forms of PD in terms of brain abnormalities using resting-state functional MRI and graph theory. Thirty-one familial PD patients and 36 sporadic PD patients underwent resting-state functional MRI scanning. Frequency-dependent functional connectivity was calculated for each subject using wavelet-based correlations of BOLD signal over 246 brain regions from Brainnetome Atlas. Graph theoretical analysis was then performed to analyze the topology of the functional network, and functional connectome differences were identified with a network-based statistical approach. Our results revealed a frequency-specific (0.016 and 0.031 Hz) connectome difference between familial and sporadic forms of PD, as indicated by an increase in assortativity and decrease in the nodal strength in the left medial amygdala of the familial PD group. In addition, the familial PD patients also showed a distinctive functional network between the left medial amygdala and regions related to retrieval of motion information. The present study indicates that the medial amygdala might be most vulnerable to both sporadic and familial PD. Our findings provide some new insights into disrupted resting-state functional connectomes between sporadic PD and familial PD. Frontiers Media S.A. 2017-11-06 /pmc/articles/PMC5681528/ /pubmed/29163072 http://dx.doi.org/10.3389/fnana.2017.00099 Text en Copyright © 2017 Tang, Xiao, Xie, Wan, Meng, Liu, Liao, Tang and Guo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tang, Yan
Xiao, Xue
Xie, Hua
Wan, Chang-min
Meng, Li
Liu, Zhen-hua
Liao, Wei-hua
Tang, Bei-sha
Guo, Ji-feng
Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients
title Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients
title_full Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients
title_fullStr Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients
title_full_unstemmed Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients
title_short Altered Functional Brain Connectomes between Sporadic and Familial Parkinson's Patients
title_sort altered functional brain connectomes between sporadic and familial parkinson's patients
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681528/
https://www.ncbi.nlm.nih.gov/pubmed/29163072
http://dx.doi.org/10.3389/fnana.2017.00099
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