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Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application

The implantable cuff electrode is an effective neuroprosthetic device in current nerve tissue engineering. However, biocompatibility and stability are still a serious dispute in terms of in vivo function and continuous monitoring. In this regard, assessing the host’s biological response to biomateri...

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Autores principales: Kim, Han-Jun, Heo, Dong Nyoung, Lee, Yi Jae, Lee, Sang Jin, Kang, Ji Yoon, Lee, Soo Hyun, Kwon, II Keun, Do, Sun Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681553/
https://www.ncbi.nlm.nih.gov/pubmed/29127334
http://dx.doi.org/10.1038/s41598-017-15551-x
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author Kim, Han-Jun
Heo, Dong Nyoung
Lee, Yi Jae
Lee, Sang Jin
Kang, Ji Yoon
Lee, Soo Hyun
Kwon, II Keun
Do, Sun Hee
author_facet Kim, Han-Jun
Heo, Dong Nyoung
Lee, Yi Jae
Lee, Sang Jin
Kang, Ji Yoon
Lee, Soo Hyun
Kwon, II Keun
Do, Sun Hee
author_sort Kim, Han-Jun
collection PubMed
description The implantable cuff electrode is an effective neuroprosthetic device in current nerve tissue engineering. However, biocompatibility and stability are still a serious dispute in terms of in vivo function and continuous monitoring. In this regard, assessing the host’s biological response to biomaterials is one of the key factors of chronic implantation. In this article, we analyzed the peripheral nerve specific-biological responses to the application of multi-functional hydrogel-coated electrodes. The surface of the cuff electrode was modified using a multifunctional hydrogel composed of PEG hydrogel, cyclosporin A(CsA)-microsphere(MS) and electrodeposited PEDOT:PSS. Through our approach, we have found that the multifunctional hydrogel coatings improve the neural electrode function, such as peak-to-peak amplitude increase. Additionally, the multifunctional hydrogel coated electrodes exhibited improved biocompatibility, such as reduced apoptotic properties and increased axonal myelination. Furthermore, 12 genes (BDNF, Gfra1, IL-6, Sox 10, S100B, P75 (NTR), GAP43, MBP, MPZ, NrCAM, NE-FL, CB1) were upregulated at 5 weeks post-implant. Finally, double immunofluorescence revealed the effect of endocannabinoid system on neuroprotective properties and tissue remodeling of peripheral nerves during cuff electrode implantation. These results clearly confirmed that multifunctional hydrogel coatings could improve electrode function and biocompatibility by enhancing neuroprotective properties, which may provide a valuable paradigm for clinical neurology application.
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spelling pubmed-56815532017-11-17 Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application Kim, Han-Jun Heo, Dong Nyoung Lee, Yi Jae Lee, Sang Jin Kang, Ji Yoon Lee, Soo Hyun Kwon, II Keun Do, Sun Hee Sci Rep Article The implantable cuff electrode is an effective neuroprosthetic device in current nerve tissue engineering. However, biocompatibility and stability are still a serious dispute in terms of in vivo function and continuous monitoring. In this regard, assessing the host’s biological response to biomaterials is one of the key factors of chronic implantation. In this article, we analyzed the peripheral nerve specific-biological responses to the application of multi-functional hydrogel-coated electrodes. The surface of the cuff electrode was modified using a multifunctional hydrogel composed of PEG hydrogel, cyclosporin A(CsA)-microsphere(MS) and electrodeposited PEDOT:PSS. Through our approach, we have found that the multifunctional hydrogel coatings improve the neural electrode function, such as peak-to-peak amplitude increase. Additionally, the multifunctional hydrogel coated electrodes exhibited improved biocompatibility, such as reduced apoptotic properties and increased axonal myelination. Furthermore, 12 genes (BDNF, Gfra1, IL-6, Sox 10, S100B, P75 (NTR), GAP43, MBP, MPZ, NrCAM, NE-FL, CB1) were upregulated at 5 weeks post-implant. Finally, double immunofluorescence revealed the effect of endocannabinoid system on neuroprotective properties and tissue remodeling of peripheral nerves during cuff electrode implantation. These results clearly confirmed that multifunctional hydrogel coatings could improve electrode function and biocompatibility by enhancing neuroprotective properties, which may provide a valuable paradigm for clinical neurology application. Nature Publishing Group UK 2017-11-10 /pmc/articles/PMC5681553/ /pubmed/29127334 http://dx.doi.org/10.1038/s41598-017-15551-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Han-Jun
Heo, Dong Nyoung
Lee, Yi Jae
Lee, Sang Jin
Kang, Ji Yoon
Lee, Soo Hyun
Kwon, II Keun
Do, Sun Hee
Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application
title Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application
title_full Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application
title_fullStr Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application
title_full_unstemmed Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application
title_short Biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application
title_sort biological assessments of multifunctional hydrogel-decorated implantable neural cuff electrode for clinical neurology application
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681553/
https://www.ncbi.nlm.nih.gov/pubmed/29127334
http://dx.doi.org/10.1038/s41598-017-15551-x
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