The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding

Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation in what way some structural modifications may impact on coor...

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Autores principales: Kotynia, Aleksandra, Krzyżak, Edward, Kamysz, Elżbieta, Sobocińska, Małgorzata, Brasuń, Justyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681609/
https://www.ncbi.nlm.nih.gov/pubmed/29170620
http://dx.doi.org/10.1007/s10989-016-9569-x
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author Kotynia, Aleksandra
Krzyżak, Edward
Kamysz, Elżbieta
Sobocińska, Małgorzata
Brasuń, Justyna
author_facet Kotynia, Aleksandra
Krzyżak, Edward
Kamysz, Elżbieta
Sobocińska, Małgorzata
Brasuń, Justyna
author_sort Kotynia, Aleksandra
collection PubMed
description Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation in what way some structural modifications may impact on coordination abilities of studied peptides. In this work we presented the interaction of pentapeptides with copper(II) ions in wide range of pH. To determine the coordination model of ligands there were carried out several studies by spectroscopy (UV–Vis, CD) methods and potentiometric measurements.
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spelling pubmed-56816092017-11-21 The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding Kotynia, Aleksandra Krzyżak, Edward Kamysz, Elżbieta Sobocińska, Małgorzata Brasuń, Justyna Int J Pept Res Ther Article Three novel analogues of salivary peptides as sialorphin (QHNPR) and opiorphin (QRFSR) were synthesized by the solid-phase method. The sequences of these ligands were following: AHNPR, QANPR and QRFPR. The aim of our work was investigation in what way some structural modifications may impact on coordination abilities of studied peptides. In this work we presented the interaction of pentapeptides with copper(II) ions in wide range of pH. To determine the coordination model of ligands there were carried out several studies by spectroscopy (UV–Vis, CD) methods and potentiometric measurements. Springer Netherlands 2017-02-04 2017 /pmc/articles/PMC5681609/ /pubmed/29170620 http://dx.doi.org/10.1007/s10989-016-9569-x Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Kotynia, Aleksandra
Krzyżak, Edward
Kamysz, Elżbieta
Sobocińska, Małgorzata
Brasuń, Justyna
The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding
title The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding
title_full The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding
title_fullStr The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding
title_full_unstemmed The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding
title_short The Coordination Abilities of Three Novel Analogues of Saliva Peptides: The Influence of Structural Modification on the Copper Binding
title_sort coordination abilities of three novel analogues of saliva peptides: the influence of structural modification on the copper binding
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681609/
https://www.ncbi.nlm.nih.gov/pubmed/29170620
http://dx.doi.org/10.1007/s10989-016-9569-x
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