Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry

Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination by calculations when the blood is seen as viscoelastic fluid. The vessel-geometry-r...

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Detalles Bibliográficos
Autores principales: Chen, Yuanyuan, Li, Donghai, Li, Yongjian, Wan, Jiandi, Li, Jiang, Chen, Haosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681636/
https://www.ncbi.nlm.nih.gov/pubmed/29127352
http://dx.doi.org/10.1038/s41598-017-15524-0
Descripción
Sumario:Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination by calculations when the blood is seen as viscoelastic fluid. The vessel-geometry-regulated margination is then confirmed by in vitro experiments in microfluidic devices, and it establishes new insights to cell sorting technology and artificial blood vessel fabrication.

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