Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry

Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination by calculations when the blood is seen as viscoelastic fluid. The vessel-geometry-r...

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Autores principales: Chen, Yuanyuan, Li, Donghai, Li, Yongjian, Wan, Jiandi, Li, Jiang, Chen, Haosheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681636/
https://www.ncbi.nlm.nih.gov/pubmed/29127352
http://dx.doi.org/10.1038/s41598-017-15524-0
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author Chen, Yuanyuan
Li, Donghai
Li, Yongjian
Wan, Jiandi
Li, Jiang
Chen, Haosheng
author_facet Chen, Yuanyuan
Li, Donghai
Li, Yongjian
Wan, Jiandi
Li, Jiang
Chen, Haosheng
author_sort Chen, Yuanyuan
collection PubMed
description Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination by calculations when the blood is seen as viscoelastic fluid. The vessel-geometry-regulated margination is then confirmed by in vitro experiments in microfluidic devices, and it establishes new insights to cell sorting technology and artificial blood vessel fabrication.
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spelling pubmed-56816362017-11-17 Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry Chen, Yuanyuan Li, Donghai Li, Yongjian Wan, Jiandi Li, Jiang Chen, Haosheng Sci Rep Article Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination by calculations when the blood is seen as viscoelastic fluid. The vessel-geometry-regulated margination is then confirmed by in vitro experiments in microfluidic devices, and it establishes new insights to cell sorting technology and artificial blood vessel fabrication. Nature Publishing Group UK 2017-11-10 /pmc/articles/PMC5681636/ /pubmed/29127352 http://dx.doi.org/10.1038/s41598-017-15524-0 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chen, Yuanyuan
Li, Donghai
Li, Yongjian
Wan, Jiandi
Li, Jiang
Chen, Haosheng
Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry
title Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry
title_full Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry
title_fullStr Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry
title_full_unstemmed Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry
title_short Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry
title_sort margination of stiffened red blood cells regulated by vessel geometry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681636/
https://www.ncbi.nlm.nih.gov/pubmed/29127352
http://dx.doi.org/10.1038/s41598-017-15524-0
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