Overexpression of DYRK1A, a Down Syndrome Candidate gene, Impairs Primordial Germ Cells Maintenance and Migration in zebrafish

DYRK1A, located on chromosome 21, is a major candidate gene of Down syndrome (DS, trisomy21), and its overexpression is associated with abnormal phenotype of Down syndrome patients. The defects of gonads and germ cells in Down Syndrome suggest that overexpression of DYRK1A has potential effect on pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yanyan, Lin, Ziyuan, Liu, Mingfeng, Wang, He, Sun, Huaqin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681638/
https://www.ncbi.nlm.nih.gov/pubmed/29127398
http://dx.doi.org/10.1038/s41598-017-15730-w

Ejemplares similares

Ejemplares similares