Structural basis of arrestin-3 activation and signaling

A unique aspect of arrestin-3 is its ability to support both receptor-dependent and receptor-independent signaling. Here, we show that inositol hexakisphosphate (IP(6)) is a non-receptor activator of arrestin-3 and report the structure of IP(6)-activated arrestin-3 at 2.4-Å resolution. IP(6)-activat...

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Detalles Bibliográficos
Autores principales: Chen, Qiuyan, Perry, Nicole A., Vishnivetskiy, Sergey A., Berndt, Sandra, Gilbert, Nathaniel C., Zhuo, Ya, Singh, Prashant K., Tholen, Jonas, Ohi, Melanie D., Gurevich, Eugenia V., Brautigam, Chad A., Klug, Candice S., Gurevich, Vsevolod V., Iverson, T. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681653/
https://www.ncbi.nlm.nih.gov/pubmed/29127291
http://dx.doi.org/10.1038/s41467-017-01218-8

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