Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP

The sodium taurocholate co-transporting polypeptide (NTCP, SLC10A1) is the main hepatic transporter of conjugated bile acids, and the entry receptor for hepatitis B virus (HBV) and hepatitis delta virus (HDV). Myrcludex B, a synthetic peptide mimicking the NTCP-binding domain of HBV, effectively blo...

Descripción completa

Detalles Bibliográficos
Autores principales: Donkers, Joanne M., Zehnder, Benno, van Westen, Gerard J. P., Kwakkenbos, Mark J., IJzerman, Adriaan P., Oude Elferink, Ronald P. J., Beuers, Ulrich, Urban, Stephan, van de Graaf, Stan F. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681660/
https://www.ncbi.nlm.nih.gov/pubmed/29127322
http://dx.doi.org/10.1038/s41598-017-15338-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681660/
https://www.ncbi.nlm.nih.gov/pubmed/29127322
http://dx.doi.org/10.1038/s41598-017-15338-0

Ejemplares similares