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Tumor suppressor NPRL2 induces ROS production and DNA damage response

The SEA/GATOR complex is an essential regulator of the mTORC1 pathway. In mammals the GATOR1 complex is composed of the proteins DEPDC5, NPRL2 and NPRL3. GATOR1 serves as an mTORC1 inhibitor and activates the mTORC1-modulating RagA GTPase. However, several GATOR members have mTORC1 independent funct...

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Detalles Bibliográficos
Autores principales:	Ma, Yinxing, Silveri, Licia, LaCava, John, Dokudovskaya, Svetlana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681675/ https://www.ncbi.nlm.nih.gov/pubmed/29127423 http://dx.doi.org/10.1038/s41598-017-15497-0

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