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Hyperglycemia Promotes TMPRSS2-ERG Gene Fusion in Prostate Cancer Cells via Upregulating Insulin-Like Growth Factor-Binding Protein-2
BACKGROUND: Epidemiologic evidence shows that obesity is associated with a greater risk of aggressive prostate cancer (PCa) and PCa-specific mortality and this is observed mainly in men with the TMPRSS2-ERG gene fusion. Obesity is often associated with comorbid conditions such as type 2 diabetes and...
Autores principales: | Holly, Jeff M. P., Broadhurst, Jessica, Mansor, Rehanna, Bahl, Amit, Perks, Claire M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681733/ https://www.ncbi.nlm.nih.gov/pubmed/29163372 http://dx.doi.org/10.3389/fendo.2017.00305 |
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