Cargando…

Ketogal: A Derivative Ketorolac Molecule with Minor Ulcerogenic and Renal Toxicity

Ketorolac is a powerful non-steroidal anti-inflammatory drug (NSAID), with a great analgesic activity, present on the Italian market since 1991. Despite the excellent therapeutic activity, the chronic use of ketorolac has long been limited owing to the high incidence of gastrointestinal and kidney s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Russo, Roberto, De Caro, Carmen, Avallone, Bice, Magliocca, Salvatore, Nieddu, Maria, Boatto, Gianpiero, Troiano, Roberta, Cuomo, Rosario, Cirillo, Carla, Avagliano, Carmen, Cristiano, Claudia, La Rana, Giovanna, Sarnelli, Giovanni, Calignano, Antonio, Rimoli, Maria G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681857/ https://www.ncbi.nlm.nih.gov/pubmed/29163153 http://dx.doi.org/10.3389/fphar.2017.00757

Ejemplares similares

Ketogal Safety Profile in Human Primary Colonic Epithelial Cells and in Mice
por: Sodano, Federica, et al.
Publicado: (2021)

Analysis of 2,5-dimethoxy-amphetamines and 2,5-dimethoxy-phenethylamines aiming their determination in biological matrices: a review
por: Nieddu, Maria, et al.
Publicado: (2022)

The Beneficial Effects of Ultramicronized Palmitoylethanolamide in the Management of Neuropathic Pain and Associated Mood Disorders Induced by Paclitaxel in Mice
por: Cristiano, Claudia, et al.
Publicado: (2022)

Analgesic and Anti-Inflammatory Effects of Perampanel in Acute and Chronic Pain Models in Mice: Interaction With the Cannabinergic System
por: De Caro, Carmen, et al.
Publicado: (2021)

Determination of Praziquantel in Sparus aurata L. after Administration of Medicated Animal Feed
por: Baralla, Elena, et al.
Publicado: (2020)

The Protective Role of Butyrate against Obesity and Obesity-Related Diseases
por: Coppola, Serena, et al.
Publicado: (2021)

Characterization of New TRPM8 Modulators in Pain Perception
por: De Caro, Carmen, et al.
Publicado: (2019)

Study of vacuolating cytotoxin A (vacA) genotypes of ulcerogenic and non-ulcerogenic strains of Helicobacter pylori and its association with gastric disease
por: Al-Ouqaili, Mushtak T.S., et al.
Publicado: (2023)

Ulcerogenic risk assessment of diets for pigs in relation to gastric lesion prevalence
por: Cappai, Maria Grazia, et al.
Publicado: (2013)

Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase
por: Cifani, Carlo, et al.
Publicado: (2020)

Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice
por: Micheli, Laura, et al.
Publicado: (2019)

Evaluation of anti-ulcerogenic properties from the root of Flemingia strobilifera
por: Anil Kumar, KV, et al.
Publicado: (2010)

Blood serum retinol levels in Asinara white donkeys reflect albinism‐induced metabolic adaptation to photoperiod at Mediterranean latitudes
por: Cappai, Maria Grazia, et al.
Publicado: (2016)

Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen
por: O'Toole, Paul W, et al.
Publicado: (2010)

Rocuronium-induced withdrawal movement: influence of ketorolac or a combination of lidocaine and ketorolac pretreatment
por: Jeon, Younghoon, et al.
Publicado: (2013)

Nutraceuticals: An integrative approach to starve Parkinson’s disease
por: Lama, Adriano, et al.
Publicado: (2020)

Dual-Hit Model of Parkinson’s Disease: Impact of Dysbiosis on 6-Hydroxydopamine-Insulted Mice—Neuroprotective and Anti-Inflammatory Effects of Butyrate
por: Avagliano, Carmen, et al.
Publicado: (2022)

Structure-activity relationships for ulcerogenic and adrenocorticolytic effects of alkyl nitriles, amines, and thiols.
por: Szabo, S, et al.
Publicado: (1975)

Anti-ulcerogenic and anti-ulcerative colitis (UC) activities of seven amines derivatives
por: Awaad, Amani S., et al.
Publicado: (2017)

Intramuscular Ketorolac Injections in the Athlete
por: Sawyer, Gregory A., et al.
Publicado: (2012)

Intracameral ketorolac concentration at the beginning and end of cataract surgery following preoperative topical ketorolac administration
por: Katsev, Douglas A, et al.
Publicado: (2017)

Low anti-ulcerogenic potentials of essential oils and methanolic extract of Croton zambesicus leaves
por: Akinlolu, Adelaja Abdulazeez, et al.
Publicado: (2014)

Evaluation of anti-inflammatory and ulcerogenic potential of zinc–ibuprofen and zinc–naproxen complexes in rats
por: Jarosz, Magdalena, et al.
Publicado: (2017)

Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants
por: El-Meligy, Reham M., et al.
Publicado: (2017)

ANTI-ULCEROGENIC EFFICACY AND MECHANISMS OF EDIBLE AND NATURAL INGREDIENTS IN NSAID-INDUCED ANIMAL MODELS
por: Bi, Weiping, et al.
Publicado: (2017)

Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases
por: Coppola, Serena, et al.
Publicado: (2022)

Ketorolac trometamina y nalbufina : estudio comparativo/
por: Morgan Pérez, Martha Elena
Publicado: (1994)

Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy
por: De Caro, Carmen, et al.
Publicado: (2019)

Benzotriazole: An overview on its versatile biological behavior
por: Briguglio, I., et al.
Publicado: (2015)

Phenolic profile, anti-inflammatory, antinociceptive, anti-ulcerogenic and hepatoprotective activities of Pimenta racemosa leaves
por: Moharram, Fatma Abd-elkader, et al.
Publicado: (2018)

Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity
por: Alasmary, Fatmah A.S., et al.
Publicado: (2018)

Evaluation of the anti-inflammatory, analgesic, anti-pyretic and anti-ulcerogenic potentials of synthetic indole derivatives
por: Siddique, Saira, et al.
Publicado: (2023)

The antiprotozoal drug pentamidine ameliorates experimentally induced acute colitis in mice
por: Esposito, Giuseppe, et al.
Publicado: (2012)

S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease
por: Cirillo, Carla, et al.
Publicado: (2015)

Biological Profile of Two Gentiana lutea L. Metabolites Using Computational Approaches and In Vitro Tests
por: De Vita, Simona, et al.
Publicado: (2021)

Ocular pharmacokinetics of 0.45% ketorolac tromethamine
por: Attar, Mayssa, et al.
Publicado: (2010)

Novel in-situ gel for intravesical administration of ketorolac
por: Sherif, Abdelrahman Y., et al.
Publicado: (2018)

Dual Actions of Ketorolac in Metastatic Ovarian Cancer
por: Hudson, Laurie G., et al.
Publicado: (2019)

Treatment of Retinopathy of Prematurity with topical ketorolac tromethamine: a preliminary study
por: Avila-Vazquez, Medardo, et al.
Publicado: (2004)

A randomized, clinical trial of ketorolac tromethamine vs ketorolac trometamine plus complex B vitamins for cesarean delivery analgesia
por: Beltrán-Montoya, J. J., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_j6emt91q4hihnq4pqht051vuts