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In Silico Assessment of Efficacy and Safety of I(Kur) Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding
Current pharmacological therapy against atrial fibrillation (AF), the most common cardiac arrhythmia, is limited by moderate efficacy and adverse side effects including ventricular proarrhythmia and organ toxicity. One way to circumvent the former is to target ion channels that are predominantly exp...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681918/ https://www.ncbi.nlm.nih.gov/pubmed/29163179 http://dx.doi.org/10.3389/fphar.2017.00799 |