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Silencing of NAC1 Expression Induces Cancer Cells Oxidative Stress in Hypoxia and Potentiates the Therapeutic Activity of Elesclomol

In order to survive under conditions of low oxygen, cancer cells can undergo a metabolic switch to glycolysis and suppress mitochondrial respiration in order to reduce oxygen consumption and prevent excessive amounts of reactive oxygen species (ROS) production. Nucleus accumbens-1 (NAC1), a nuclear...

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Detalles Bibliográficos
Autores principales:	Ren, Yi-Jie, Wang, Xiao-Hui, Ji, Cheng, Guan, Yi-Di, Lu, Xian-Jiu, Liu, Xian-Rong, Zhang, Hong-Han, Guo, Ling-Chuan, Xu, Qiong-Hua, Zhu, Wei-Dong, Ming, Zhi-Jun, Yang, Jin-Ming, Cheng, Yan, Zhang, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681923/ https://www.ncbi.nlm.nih.gov/pubmed/29163184 http://dx.doi.org/10.3389/fphar.2017.00804

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