Dietary and Microbial Metabolites in the Regulation of Host Immunity

Mucosal surfaces in the body, especially the intestine, are constantly exposed to trillions of microbiomes. Accumulating evidence has revealed that changes in the composition of the gut microbiome, especially that of the commensal bacteria population, are frequently associated with immunologic disor...

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Detalles Bibliográficos
Autores principales: Shibata, Naoko, Kunisawa, Jun, Kiyono, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681998/
https://www.ncbi.nlm.nih.gov/pubmed/29163449
http://dx.doi.org/10.3389/fmicb.2017.02171
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author Shibata, Naoko
Kunisawa, Jun
Kiyono, Hiroshi
author_facet Shibata, Naoko
Kunisawa, Jun
Kiyono, Hiroshi
author_sort Shibata, Naoko
collection PubMed
description Mucosal surfaces in the body, especially the intestine, are constantly exposed to trillions of microbiomes. Accumulating evidence has revealed that changes in the composition of the gut microbiome, especially that of the commensal bacteria population, are frequently associated with immunologic disorders. These changes coincide with changes in the production of certain dietary metabolites. Recent studies have uncovered the molecular and cellular mechanisms underlying the relationships among diet, commensal bacteria, and the host immune system. In this review, we describe how dietary and microbial metabolites modulate host immunity.
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spelling pubmed-56819982017-11-21 Dietary and Microbial Metabolites in the Regulation of Host Immunity Shibata, Naoko Kunisawa, Jun Kiyono, Hiroshi Front Microbiol Microbiology Mucosal surfaces in the body, especially the intestine, are constantly exposed to trillions of microbiomes. Accumulating evidence has revealed that changes in the composition of the gut microbiome, especially that of the commensal bacteria population, are frequently associated with immunologic disorders. These changes coincide with changes in the production of certain dietary metabolites. Recent studies have uncovered the molecular and cellular mechanisms underlying the relationships among diet, commensal bacteria, and the host immune system. In this review, we describe how dietary and microbial metabolites modulate host immunity. Frontiers Media S.A. 2017-11-07 /pmc/articles/PMC5681998/ /pubmed/29163449 http://dx.doi.org/10.3389/fmicb.2017.02171 Text en Copyright © 2017 Shibata, Kunisawa and Kiyono. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Shibata, Naoko
Kunisawa, Jun
Kiyono, Hiroshi
Dietary and Microbial Metabolites in the Regulation of Host Immunity
title Dietary and Microbial Metabolites in the Regulation of Host Immunity
title_full Dietary and Microbial Metabolites in the Regulation of Host Immunity
title_fullStr Dietary and Microbial Metabolites in the Regulation of Host Immunity
title_full_unstemmed Dietary and Microbial Metabolites in the Regulation of Host Immunity
title_short Dietary and Microbial Metabolites in the Regulation of Host Immunity
title_sort dietary and microbial metabolites in the regulation of host immunity
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681998/
https://www.ncbi.nlm.nih.gov/pubmed/29163449
http://dx.doi.org/10.3389/fmicb.2017.02171
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