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Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say
Pest control in the agricultural fields, a major concern globally, is currently achieved through chemical or biological methods. Chemical methods, which leave toxic residue in the produce, are less preferred than biological methods. Venoms injected by stings of various wasps that kill the pest is co...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682083/ https://www.ncbi.nlm.nih.gov/pubmed/29213193 http://dx.doi.org/10.1155/2017/6978194 |
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author | Saba, Evelyn Shafeeq, Tahir Irfan, Muhammad Lee, Yuan Yee Kwon, Hyuk-Woo Seo, Myung Gi Park, Sang-Joon Lee, Kyeong-Yeoll Rhee, Man Hee |
author_facet | Saba, Evelyn Shafeeq, Tahir Irfan, Muhammad Lee, Yuan Yee Kwon, Hyuk-Woo Seo, Myung Gi Park, Sang-Joon Lee, Kyeong-Yeoll Rhee, Man Hee |
author_sort | Saba, Evelyn |
collection | PubMed |
description | Pest control in the agricultural fields, a major concern globally, is currently achieved through chemical or biological methods. Chemical methods, which leave toxic residue in the produce, are less preferred than biological methods. Venoms injected by stings of various wasps that kill the pest is considered as the examples of the biological method. Although several studies have investigated the biological control of pests through these venoms, very few studies have reported the effects of these venoms on mammalian cells. Bracon hebetor, an ectoparasitoid of the order Hymenoptera, is having a paramount importance in parasitizing various lepidopterous larvae including Plodia interpunctella also called as Indianmeal moth (IMM). Since it is biologically controlled by B. hebetor venom, therefore in our study, herein for the first time, we report the anti-inflammatory activities of the venom from B. hebetor (BHV). We developed a septic shock mice model for in vivo anti-inflammatory studies and RAW 264.7 cells for in vitro studies. Our results clearly demonstrate that BHV can dose dependently abrogate the nitric oxide (NO) production and suppress the levels of proinflammatory mediators and cytokines without posing any cytotoxicity via the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways. |
format | Online Article Text |
id | pubmed-5682083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-56820832017-12-06 Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say Saba, Evelyn Shafeeq, Tahir Irfan, Muhammad Lee, Yuan Yee Kwon, Hyuk-Woo Seo, Myung Gi Park, Sang-Joon Lee, Kyeong-Yeoll Rhee, Man Hee Mediators Inflamm Research Article Pest control in the agricultural fields, a major concern globally, is currently achieved through chemical or biological methods. Chemical methods, which leave toxic residue in the produce, are less preferred than biological methods. Venoms injected by stings of various wasps that kill the pest is considered as the examples of the biological method. Although several studies have investigated the biological control of pests through these venoms, very few studies have reported the effects of these venoms on mammalian cells. Bracon hebetor, an ectoparasitoid of the order Hymenoptera, is having a paramount importance in parasitizing various lepidopterous larvae including Plodia interpunctella also called as Indianmeal moth (IMM). Since it is biologically controlled by B. hebetor venom, therefore in our study, herein for the first time, we report the anti-inflammatory activities of the venom from B. hebetor (BHV). We developed a septic shock mice model for in vivo anti-inflammatory studies and RAW 264.7 cells for in vitro studies. Our results clearly demonstrate that BHV can dose dependently abrogate the nitric oxide (NO) production and suppress the levels of proinflammatory mediators and cytokines without posing any cytotoxicity via the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways. Hindawi 2017 2017-10-29 /pmc/articles/PMC5682083/ /pubmed/29213193 http://dx.doi.org/10.1155/2017/6978194 Text en Copyright © 2017 Evelyn Saba et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Saba, Evelyn Shafeeq, Tahir Irfan, Muhammad Lee, Yuan Yee Kwon, Hyuk-Woo Seo, Myung Gi Park, Sang-Joon Lee, Kyeong-Yeoll Rhee, Man Hee Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say |
title | Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say |
title_full | Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say |
title_fullStr | Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say |
title_full_unstemmed | Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say |
title_short | Anti-Inflammatory Activity of Crude Venom Isolated from Parasitoid Wasp, Bracon hebetor Say |
title_sort | anti-inflammatory activity of crude venom isolated from parasitoid wasp, bracon hebetor say |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682083/ https://www.ncbi.nlm.nih.gov/pubmed/29213193 http://dx.doi.org/10.1155/2017/6978194 |
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