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Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis

PURPOSE: To estimate both direct and indirect effects (through obesity) of serum uric acid (SUA) on blood sugar in prediabetes patients. METHODS: Prediabetes patients who came to the outpatient clinic of the Department of Family Medicine, Ramathibodi Hospital, were included in this cross-sectional s...

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Autores principales: Anothaisintawee, Thunyarat, Lertrattananon, Dumrongrat, Thamakaison, Sangsulee, Reutrakul, Sirimon, Ongphiphadhanakul, Boonsong, Thakkinstian, Ammarin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682093/
https://www.ncbi.nlm.nih.gov/pubmed/29214183
http://dx.doi.org/10.1155/2017/6830671
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author Anothaisintawee, Thunyarat
Lertrattananon, Dumrongrat
Thamakaison, Sangsulee
Reutrakul, Sirimon
Ongphiphadhanakul, Boonsong
Thakkinstian, Ammarin
author_facet Anothaisintawee, Thunyarat
Lertrattananon, Dumrongrat
Thamakaison, Sangsulee
Reutrakul, Sirimon
Ongphiphadhanakul, Boonsong
Thakkinstian, Ammarin
author_sort Anothaisintawee, Thunyarat
collection PubMed
description PURPOSE: To estimate both direct and indirect effects (through obesity) of serum uric acid (SUA) on blood sugar in prediabetes patients. METHODS: Prediabetes patients who came to the outpatient clinic of the Department of Family Medicine, Ramathibodi Hospital, were included in this cross-sectional study. Mediation analysis was applied to determine direct and indirect effects of SUA on glycemic parameters (fasting plasma glucose (FPG) and HbA1c) through waist circumference (WC). A mediation effect was estimated using the product-of-coefficient method with a bootstrap analysis of 1000 replications. RESULTS: 1043 patients were eligible for this study. Every 1 mg/dl increase in SUA was associated with an increase in WC and then was significantly associated with an increase in FPG by 0.082 mg/dl (95% CI: 0.010, 0.154). SUA was directly associated with FPG with a coefficient of 0.413 (95% CI: 0.049, 0.776). For HbA1c, every one mg/dl increase in SUA was associated with an increase in HbA1c level through WC by 0.006 (95% CI: 0.003, 0.010). However, SUA was not directly associated with HbA1c. CONCLUSIONS: We found that an increase in SUA was directly and indirectly associated with increased FPG but the effect of SUA on HbA1c was shown when it was mediated through WC.
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spelling pubmed-56820932017-12-06 Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis Anothaisintawee, Thunyarat Lertrattananon, Dumrongrat Thamakaison, Sangsulee Reutrakul, Sirimon Ongphiphadhanakul, Boonsong Thakkinstian, Ammarin J Diabetes Res Research Article PURPOSE: To estimate both direct and indirect effects (through obesity) of serum uric acid (SUA) on blood sugar in prediabetes patients. METHODS: Prediabetes patients who came to the outpatient clinic of the Department of Family Medicine, Ramathibodi Hospital, were included in this cross-sectional study. Mediation analysis was applied to determine direct and indirect effects of SUA on glycemic parameters (fasting plasma glucose (FPG) and HbA1c) through waist circumference (WC). A mediation effect was estimated using the product-of-coefficient method with a bootstrap analysis of 1000 replications. RESULTS: 1043 patients were eligible for this study. Every 1 mg/dl increase in SUA was associated with an increase in WC and then was significantly associated with an increase in FPG by 0.082 mg/dl (95% CI: 0.010, 0.154). SUA was directly associated with FPG with a coefficient of 0.413 (95% CI: 0.049, 0.776). For HbA1c, every one mg/dl increase in SUA was associated with an increase in HbA1c level through WC by 0.006 (95% CI: 0.003, 0.010). However, SUA was not directly associated with HbA1c. CONCLUSIONS: We found that an increase in SUA was directly and indirectly associated with increased FPG but the effect of SUA on HbA1c was shown when it was mediated through WC. Hindawi 2017 2017-10-29 /pmc/articles/PMC5682093/ /pubmed/29214183 http://dx.doi.org/10.1155/2017/6830671 Text en Copyright © 2017 Thunyarat Anothaisintawee et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Anothaisintawee, Thunyarat
Lertrattananon, Dumrongrat
Thamakaison, Sangsulee
Reutrakul, Sirimon
Ongphiphadhanakul, Boonsong
Thakkinstian, Ammarin
Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis
title Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis
title_full Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis
title_fullStr Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis
title_full_unstemmed Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis
title_short Direct and Indirect Effects of Serum Uric Acid on Blood Sugar Levels in Patients with Prediabetes: A Mediation Analysis
title_sort direct and indirect effects of serum uric acid on blood sugar levels in patients with prediabetes: a mediation analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682093/
https://www.ncbi.nlm.nih.gov/pubmed/29214183
http://dx.doi.org/10.1155/2017/6830671
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