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Divergent neural responses to narrative speech in disorders of consciousness

OBJECTIVE: Clinical assessment of auditory attention in patients with disorders of consciousness is often limited by motor impairment. Here, we employ intersubject correlations among electroencephalography responses to naturalistic speech in order to assay auditory attention among patients and healt...

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Autores principales: Iotzov, Ivan, Fidali, Brian C., Petroni, Agustin, Conte, Mary M., Schiff, Nicholas D., Parra, Lucas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682119/
https://www.ncbi.nlm.nih.gov/pubmed/29159190
http://dx.doi.org/10.1002/acn3.470
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author Iotzov, Ivan
Fidali, Brian C.
Petroni, Agustin
Conte, Mary M.
Schiff, Nicholas D.
Parra, Lucas C.
author_facet Iotzov, Ivan
Fidali, Brian C.
Petroni, Agustin
Conte, Mary M.
Schiff, Nicholas D.
Parra, Lucas C.
author_sort Iotzov, Ivan
collection PubMed
description OBJECTIVE: Clinical assessment of auditory attention in patients with disorders of consciousness is often limited by motor impairment. Here, we employ intersubject correlations among electroencephalography responses to naturalistic speech in order to assay auditory attention among patients and healthy controls. METHODS: Electroencephalographic data were recorded from 20 subjects with disorders of consciousness and 14 healthy controls during of two narrative audio stimuli, presented both forwards and time‐reversed. Intersubject correlation of evoked electroencephalography signals were calculated, comparing responses of both groups to those of the healthy control subjects. This analysis was performed blinded and subsequently compared to the diagnostic status of each patient based on the Coma Recovery Scale‐Revised. RESULTS: Subjects with disorders of consciousness exhibit significantly lower intersubject correlation than healthy controls during narrative speech. Additionally, while healthy subjects had higher intersubject correlation values in forwards versus backwards presentation, neural responses did not vary significantly with the direction of playback in subjects with disorders of consciousness. Increased intersubject correlation values in the backward speech condition were noted with improving disorder of consciousness diagnosis, both in cross‐sectional analysis and in a subset of patients with longitudinal data. INTERPRETATION: Intersubject correlation of neural responses to narrative speech audition differentiates healthy controls from patients and appears to index clinical diagnoses in disorders of consciousness.
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spelling pubmed-56821192017-11-20 Divergent neural responses to narrative speech in disorders of consciousness Iotzov, Ivan Fidali, Brian C. Petroni, Agustin Conte, Mary M. Schiff, Nicholas D. Parra, Lucas C. Ann Clin Transl Neurol Research Articles OBJECTIVE: Clinical assessment of auditory attention in patients with disorders of consciousness is often limited by motor impairment. Here, we employ intersubject correlations among electroencephalography responses to naturalistic speech in order to assay auditory attention among patients and healthy controls. METHODS: Electroencephalographic data were recorded from 20 subjects with disorders of consciousness and 14 healthy controls during of two narrative audio stimuli, presented both forwards and time‐reversed. Intersubject correlation of evoked electroencephalography signals were calculated, comparing responses of both groups to those of the healthy control subjects. This analysis was performed blinded and subsequently compared to the diagnostic status of each patient based on the Coma Recovery Scale‐Revised. RESULTS: Subjects with disorders of consciousness exhibit significantly lower intersubject correlation than healthy controls during narrative speech. Additionally, while healthy subjects had higher intersubject correlation values in forwards versus backwards presentation, neural responses did not vary significantly with the direction of playback in subjects with disorders of consciousness. Increased intersubject correlation values in the backward speech condition were noted with improving disorder of consciousness diagnosis, both in cross‐sectional analysis and in a subset of patients with longitudinal data. INTERPRETATION: Intersubject correlation of neural responses to narrative speech audition differentiates healthy controls from patients and appears to index clinical diagnoses in disorders of consciousness. John Wiley and Sons Inc. 2017-09-27 /pmc/articles/PMC5682119/ /pubmed/29159190 http://dx.doi.org/10.1002/acn3.470 Text en © 2017 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Iotzov, Ivan
Fidali, Brian C.
Petroni, Agustin
Conte, Mary M.
Schiff, Nicholas D.
Parra, Lucas C.
Divergent neural responses to narrative speech in disorders of consciousness
title Divergent neural responses to narrative speech in disorders of consciousness
title_full Divergent neural responses to narrative speech in disorders of consciousness
title_fullStr Divergent neural responses to narrative speech in disorders of consciousness
title_full_unstemmed Divergent neural responses to narrative speech in disorders of consciousness
title_short Divergent neural responses to narrative speech in disorders of consciousness
title_sort divergent neural responses to narrative speech in disorders of consciousness
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682119/
https://www.ncbi.nlm.nih.gov/pubmed/29159190
http://dx.doi.org/10.1002/acn3.470
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