Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer

PURPOSE OF REVIEW: This review aims to evaluate research surrounding the utility of urinary biomarkers to detect bladder cancer and predict recurrence. RECENT FINDINGS: Recent research has focussed on the evaluation of genetic markers found in urine to provide diagnostic and prognostic information....

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Autor principal: Leiblich, Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Urosurgery (P Sooriakumaran, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682315/
https://www.ncbi.nlm.nih.gov/pubmed/29130146
http://dx.doi.org/10.1007/s11934-017-0748-x
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author Leiblich, Aaron
author_facet Leiblich, Aaron
author_sort Leiblich, Aaron
collection PubMed
description PURPOSE OF REVIEW: This review aims to evaluate research surrounding the utility of urinary biomarkers to detect bladder cancer and predict recurrence. RECENT FINDINGS: Recent research has focussed on the evaluation of genetic markers found in urine to provide diagnostic and prognostic information. Furthermore, the isolation and characterisation of extracellular vesicles (EVs) from the urine patients with bladder cancer provide an exciting new development in biomarker research that is set to expand in the coming years. SUMMARY: Current urinary biomarker research is a broad field that encompasses the evaluation of urinary proteins, DNA, RNA and EVs to detect signatures that can be used to predict the presence of bladder cancer and provide prognostic information. EVs in particular offer an exciting and novel perspective in the search for accurate bladder cancer biomarkers.
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spelling pubmed-56823152017-11-30 Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer Leiblich, Aaron Curr Urol Rep Urosurgery (P Sooriakumaran, Section Editor) PURPOSE OF REVIEW: This review aims to evaluate research surrounding the utility of urinary biomarkers to detect bladder cancer and predict recurrence. RECENT FINDINGS: Recent research has focussed on the evaluation of genetic markers found in urine to provide diagnostic and prognostic information. Furthermore, the isolation and characterisation of extracellular vesicles (EVs) from the urine patients with bladder cancer provide an exciting new development in biomarker research that is set to expand in the coming years. SUMMARY: Current urinary biomarker research is a broad field that encompasses the evaluation of urinary proteins, DNA, RNA and EVs to detect signatures that can be used to predict the presence of bladder cancer and provide prognostic information. EVs in particular offer an exciting and novel perspective in the search for accurate bladder cancer biomarkers. Springer US 2017-11-13 2017 /pmc/articles/PMC5682315/ /pubmed/29130146 http://dx.doi.org/10.1007/s11934-017-0748-x Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Urosurgery (P Sooriakumaran, Section Editor)
Leiblich, Aaron
Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer
title Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer
title_full Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer
title_fullStr Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer
title_full_unstemmed Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer
title_short Recent Developments in the Search for Urinary Biomarkers in Bladder Cancer
title_sort recent developments in the search for urinary biomarkers in bladder cancer
topic Urosurgery (P Sooriakumaran, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682315/
https://www.ncbi.nlm.nih.gov/pubmed/29130146
http://dx.doi.org/10.1007/s11934-017-0748-x
work_keys_str_mv AT leiblichaaron recentdevelopmentsinthesearchforurinarybiomarkersinbladdercancer

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