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Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models
In an earlier report, we demonstrated an antipsychotic-like activity of a methanolic extract of Morinda citrifolia Linn fruit in mouse models and postulated the contribution of its bioactive principles, scopoletin and rutin. Moreover, the antidopaminergic activities of scopoletin and rutin were repo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japanese Association for Laboratory Animal Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682354/ https://www.ncbi.nlm.nih.gov/pubmed/28701621 http://dx.doi.org/10.1538/expanim.17-0050 |
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author | Pandy, Vijayapandi Vijeepallam, Kamini |
author_facet | Pandy, Vijayapandi Vijeepallam, Kamini |
author_sort | Pandy, Vijayapandi |
collection | PubMed |
description | In an earlier report, we demonstrated an antipsychotic-like activity of a methanolic extract of Morinda citrifolia Linn fruit in mouse models and postulated the contribution of its bioactive principles, scopoletin and rutin. Moreover, the antidopaminergic activities of scopoletin and rutin were reported in isolated vas deferens preparations. In the present study, scopoletin and rutin were assessed for antipsychotic-like activity using apomorphine-induced climbing behavior and methamphetamine-induced stereotypy in mice. The results of this study revealed that scopoletin and rutin (0.05, 0.1, 0.5, and 1 mg/kg, p.o.) had a “U-shaped” dose-dependent effect on climbing and stereotyped behaviors induced by apomorphine and methamphetamine, respectively, in mice. A significant reduction in climbing and stereotyped behaviors caused by scopoletin and rutin was observed only at a dose 0.1 mg/kg. This study suggests that scopoletin and rutin can alleviate positive symptoms of schizophrenia only at a specific dose. Further studies evaluating the effects of scopoletin and rutin on animal models for negative symptoms of schizophrenia are required for a novel drug discovery in the treatment of neuropsychiatric diseases. |
format | Online Article Text |
id | pubmed-5682354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-56823542017-11-16 Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models Pandy, Vijayapandi Vijeepallam, Kamini Exp Anim Original In an earlier report, we demonstrated an antipsychotic-like activity of a methanolic extract of Morinda citrifolia Linn fruit in mouse models and postulated the contribution of its bioactive principles, scopoletin and rutin. Moreover, the antidopaminergic activities of scopoletin and rutin were reported in isolated vas deferens preparations. In the present study, scopoletin and rutin were assessed for antipsychotic-like activity using apomorphine-induced climbing behavior and methamphetamine-induced stereotypy in mice. The results of this study revealed that scopoletin and rutin (0.05, 0.1, 0.5, and 1 mg/kg, p.o.) had a “U-shaped” dose-dependent effect on climbing and stereotyped behaviors induced by apomorphine and methamphetamine, respectively, in mice. A significant reduction in climbing and stereotyped behaviors caused by scopoletin and rutin was observed only at a dose 0.1 mg/kg. This study suggests that scopoletin and rutin can alleviate positive symptoms of schizophrenia only at a specific dose. Further studies evaluating the effects of scopoletin and rutin on animal models for negative symptoms of schizophrenia are required for a novel drug discovery in the treatment of neuropsychiatric diseases. Japanese Association for Laboratory Animal Science 2017-07-12 2017 /pmc/articles/PMC5682354/ /pubmed/28701621 http://dx.doi.org/10.1538/expanim.17-0050 Text en ©2017 Japanese Association for Laboratory Animal Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Original Pandy, Vijayapandi Vijeepallam, Kamini Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models |
title | Antipsychotic-like activity of scopoletin and rutin against the positive
symptoms of schizophrenia in mouse models |
title_full | Antipsychotic-like activity of scopoletin and rutin against the positive
symptoms of schizophrenia in mouse models |
title_fullStr | Antipsychotic-like activity of scopoletin and rutin against the positive
symptoms of schizophrenia in mouse models |
title_full_unstemmed | Antipsychotic-like activity of scopoletin and rutin against the positive
symptoms of schizophrenia in mouse models |
title_short | Antipsychotic-like activity of scopoletin and rutin against the positive
symptoms of schizophrenia in mouse models |
title_sort | antipsychotic-like activity of scopoletin and rutin against the positive
symptoms of schizophrenia in mouse models |
topic | Original |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682354/ https://www.ncbi.nlm.nih.gov/pubmed/28701621 http://dx.doi.org/10.1538/expanim.17-0050 |
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