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Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models

In an earlier report, we demonstrated an antipsychotic-like activity of a methanolic extract of Morinda citrifolia Linn fruit in mouse models and postulated the contribution of its bioactive principles, scopoletin and rutin. Moreover, the antidopaminergic activities of scopoletin and rutin were repo...

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Autores principales: Pandy, Vijayapandi, Vijeepallam, Kamini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682354/
https://www.ncbi.nlm.nih.gov/pubmed/28701621
http://dx.doi.org/10.1538/expanim.17-0050
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author Pandy, Vijayapandi
Vijeepallam, Kamini
author_facet Pandy, Vijayapandi
Vijeepallam, Kamini
author_sort Pandy, Vijayapandi
collection PubMed
description In an earlier report, we demonstrated an antipsychotic-like activity of a methanolic extract of Morinda citrifolia Linn fruit in mouse models and postulated the contribution of its bioactive principles, scopoletin and rutin. Moreover, the antidopaminergic activities of scopoletin and rutin were reported in isolated vas deferens preparations. In the present study, scopoletin and rutin were assessed for antipsychotic-like activity using apomorphine-induced climbing behavior and methamphetamine-induced stereotypy in mice. The results of this study revealed that scopoletin and rutin (0.05, 0.1, 0.5, and 1 mg/kg, p.o.) had a “U-shaped” dose-dependent effect on climbing and stereotyped behaviors induced by apomorphine and methamphetamine, respectively, in mice. A significant reduction in climbing and stereotyped behaviors caused by scopoletin and rutin was observed only at a dose 0.1 mg/kg. This study suggests that scopoletin and rutin can alleviate positive symptoms of schizophrenia only at a specific dose. Further studies evaluating the effects of scopoletin and rutin on animal models for negative symptoms of schizophrenia are required for a novel drug discovery in the treatment of neuropsychiatric diseases.
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spelling pubmed-56823542017-11-16 Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models Pandy, Vijayapandi Vijeepallam, Kamini Exp Anim Original In an earlier report, we demonstrated an antipsychotic-like activity of a methanolic extract of Morinda citrifolia Linn fruit in mouse models and postulated the contribution of its bioactive principles, scopoletin and rutin. Moreover, the antidopaminergic activities of scopoletin and rutin were reported in isolated vas deferens preparations. In the present study, scopoletin and rutin were assessed for antipsychotic-like activity using apomorphine-induced climbing behavior and methamphetamine-induced stereotypy in mice. The results of this study revealed that scopoletin and rutin (0.05, 0.1, 0.5, and 1 mg/kg, p.o.) had a “U-shaped” dose-dependent effect on climbing and stereotyped behaviors induced by apomorphine and methamphetamine, respectively, in mice. A significant reduction in climbing and stereotyped behaviors caused by scopoletin and rutin was observed only at a dose 0.1 mg/kg. This study suggests that scopoletin and rutin can alleviate positive symptoms of schizophrenia only at a specific dose. Further studies evaluating the effects of scopoletin and rutin on animal models for negative symptoms of schizophrenia are required for a novel drug discovery in the treatment of neuropsychiatric diseases. Japanese Association for Laboratory Animal Science 2017-07-12 2017 /pmc/articles/PMC5682354/ /pubmed/28701621 http://dx.doi.org/10.1538/expanim.17-0050 Text en ©2017 Japanese Association for Laboratory Animal Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original
Pandy, Vijayapandi
Vijeepallam, Kamini
Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models
title Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models
title_full Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models
title_fullStr Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models
title_full_unstemmed Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models
title_short Antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models
title_sort antipsychotic-like activity of scopoletin and rutin against the positive symptoms of schizophrenia in mouse models
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682354/
https://www.ncbi.nlm.nih.gov/pubmed/28701621
http://dx.doi.org/10.1538/expanim.17-0050
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