Sexual dimorphism of AMBRA1-related autistic features in human and mouse

Ambra1 is linked to autophagy and neurodevelopment. Heterozygous Ambra1 deficiency induces autism-like behavior in a sexually dimorphic manner. Extraordinarily, autistic features are seen in female mice only, combined with stronger Ambra1 protein reduction in brain compared to males. However, signif...

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Detalles Bibliográficos
Autores principales: Mitjans, M, Begemann, M, Ju, A, Dere, E, Wüstefeld, L, Hofer, S, Hassouna, I, Balkenhol, J, Oliveira, B, van der Auwera, S, Tammer, R, Hammerschmidt, K, Völzke, H, Homuth, G, Cecconi, F, Chowdhury, K, Grabe, H, Frahm, J, Boretius, S, Dandekar, T, Ehrenreich, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682605/
https://www.ncbi.nlm.nih.gov/pubmed/28994820
http://dx.doi.org/10.1038/tp.2017.213

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