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Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo

Osteosarcoma is one of the most malignant neoplasms in adolescents, and it generally develops multidrug resistance. Escin, a natural mixture of triterpene saponins isolated from Aesculus hippocastanum (horse chestnut), has demonstrated potent anti-tumour potential in vitro and in vivo. In the presen...

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Detalles Bibliográficos
Autores principales:	Zhu, Jian, Yu, Wei, Liu, Bing, Wang, Yitian, shao, Jianlin, Wang, Junjie, Xia, Kaishun, Liang, Chengzhen, Fang, Weijing, Zhou, Chenhe, Tao, Huimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682655/ https://www.ncbi.nlm.nih.gov/pubmed/29022891 http://dx.doi.org/10.1038/cddis.2017.488

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