Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-κB-dependent neuroinflammation to improve functional recovery after spinal cord injury

Therapeutics used to treat central nervous system (CNS) injury were designed to repair neurites and inhibit cell apoptosis. Previous studies have shown that neuron-derived FGF10 exerts potential neuroprotective effects after cerebral ischemia injury. However, little is known about the role of endoge...

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Detalles Bibliográficos
Autores principales: Chen, Jian, Wang, Zhouguang, Zheng, ZengMing, Chen, Yu, Khor, Sinan, Shi, KeSi, He, ZiLi, Wang, Qingqing, Zhao, Yingzheng, Zhang, Hongyu, Li, Xiaokun, Li, Jiawei, Yin, Jiayu, Wang, Xiangyang, Xiao, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682656/
https://www.ncbi.nlm.nih.gov/pubmed/28981091
http://dx.doi.org/10.1038/cddis.2017.490

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