Cargando…
Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study
To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT). Polymerase chain rea...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682770/ https://www.ncbi.nlm.nih.gov/pubmed/29095251 http://dx.doi.org/10.1097/MD.0000000000008202 |
_version_ | 1783278167789666304 |
---|---|
author | Chen, Haihui Wu, Mengxin Li, Guisheng Hua, Li Chen, Shaojun Huang, Haixin |
author_facet | Chen, Haihui Wu, Mengxin Li, Guisheng Hua, Li Chen, Shaojun Huang, Haixin |
author_sort | Chen, Haihui |
collection | PubMed |
description | To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the SNP of the XRCC1 codon 399 in 114 NPC patients before radiotherapy. The risk of patients with the Arg/Arg genotype suffering from acute radiation dermatitis Grade ≥2 was higher than the other 2 genotypes (P = .014, 95% CI: 1.182–4.582). No significant difference was observed in the degree of acute radiation oral mucositis injury among the patients with different genotypes (P = .449, 95% CI: 0.691–2.304). Multivariate analysis showed that N stage and genotype were significantly associated with acute radiation dermatitis of Grade ≥2 (OR = 3.221, P < .001, 95% CI: 1.669–6.216, OR = 2.860, P = .006, 95% CI: 1.354–6.043). T stage and smoking status were significantly associated with acute radiation oral mucositis with Grade ≥2 (OR = 2.508, P = .001, 95% CI: 1.427–4.408, OR = 6.355, P < .001, 95% CI: 2.533–15.841). The XRCC1 codon 399 genotype in NPC could be an important predicting factor in the risk of acute radiation dermatitis during IMRT. |
format | Online Article Text |
id | pubmed-5682770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-56827702017-11-28 Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study Chen, Haihui Wu, Mengxin Li, Guisheng Hua, Li Chen, Shaojun Huang, Haixin Medicine (Baltimore) 5700 To explore the association of the X-ray repair cross-complementing gene 1 (XRCC1) codon 399 single-nucleotide polymorphism (SNP) with acute radiation dermatitis and oral mucositis in nasopharyngeal carcinoma (NPC) patients treated by intensity-modulated radiation therapy (IMRT). Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect the SNP of the XRCC1 codon 399 in 114 NPC patients before radiotherapy. The risk of patients with the Arg/Arg genotype suffering from acute radiation dermatitis Grade ≥2 was higher than the other 2 genotypes (P = .014, 95% CI: 1.182–4.582). No significant difference was observed in the degree of acute radiation oral mucositis injury among the patients with different genotypes (P = .449, 95% CI: 0.691–2.304). Multivariate analysis showed that N stage and genotype were significantly associated with acute radiation dermatitis of Grade ≥2 (OR = 3.221, P < .001, 95% CI: 1.669–6.216, OR = 2.860, P = .006, 95% CI: 1.354–6.043). T stage and smoking status were significantly associated with acute radiation oral mucositis with Grade ≥2 (OR = 2.508, P = .001, 95% CI: 1.427–4.408, OR = 6.355, P < .001, 95% CI: 2.533–15.841). The XRCC1 codon 399 genotype in NPC could be an important predicting factor in the risk of acute radiation dermatitis during IMRT. Wolters Kluwer Health 2017-11-03 /pmc/articles/PMC5682770/ /pubmed/29095251 http://dx.doi.org/10.1097/MD.0000000000008202 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 5700 Chen, Haihui Wu, Mengxin Li, Guisheng Hua, Li Chen, Shaojun Huang, Haixin Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study |
title | Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study |
title_full | Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study |
title_fullStr | Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study |
title_full_unstemmed | Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study |
title_short | Association between XRCC1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: A cohort study |
title_sort | association between xrcc1 single-nucleotide polymorphism and acute radiation reaction in patients with nasopharyngeal carcinoma: a cohort study |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682770/ https://www.ncbi.nlm.nih.gov/pubmed/29095251 http://dx.doi.org/10.1097/MD.0000000000008202 |
work_keys_str_mv | AT chenhaihui associationbetweenxrcc1singlenucleotidepolymorphismandacuteradiationreactioninpatientswithnasopharyngealcarcinomaacohortstudy AT wumengxin associationbetweenxrcc1singlenucleotidepolymorphismandacuteradiationreactioninpatientswithnasopharyngealcarcinomaacohortstudy AT liguisheng associationbetweenxrcc1singlenucleotidepolymorphismandacuteradiationreactioninpatientswithnasopharyngealcarcinomaacohortstudy AT huali associationbetweenxrcc1singlenucleotidepolymorphismandacuteradiationreactioninpatientswithnasopharyngealcarcinomaacohortstudy AT chenshaojun associationbetweenxrcc1singlenucleotidepolymorphismandacuteradiationreactioninpatientswithnasopharyngealcarcinomaacohortstudy AT huanghaixin associationbetweenxrcc1singlenucleotidepolymorphismandacuteradiationreactioninpatientswithnasopharyngealcarcinomaacohortstudy |