Cargando…
The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia
Iron is an intracellular element whose accumulation in the body is associated with tissue damage. This study examines the effect of iron on pediatric acute lymphoblastic leukemia (ALL) and its “response to treatment.” At the end of the first year of treatment, bone marrow iron store (BMIS) was evalu...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682830/ https://www.ncbi.nlm.nih.gov/pubmed/29095311 http://dx.doi.org/10.1097/MD.0000000000008511 |
_version_ | 1783278182252675072 |
---|---|
author | Moafi, Alireza Ziaie, Mozhdeh Abedi, Marjan Rahgozar, Soheila Reisi, Nahid Nematollahi, Pardis Moafi, Hadi |
author_facet | Moafi, Alireza Ziaie, Mozhdeh Abedi, Marjan Rahgozar, Soheila Reisi, Nahid Nematollahi, Pardis Moafi, Hadi |
author_sort | Moafi, Alireza |
collection | PubMed |
description | Iron is an intracellular element whose accumulation in the body is associated with tissue damage. This study examines the effect of iron on pediatric acute lymphoblastic leukemia (ALL) and its “response to treatment.” At the end of the first year of treatment, bone marrow iron store (BMIS) was evaluated in children with ALL and the relationship between iron store and minimal residual disease was investigated. Moreover, the 3-year disease-free survival (3-DFS) of patients was determined. Patients’ BMIS were compared with that of subjects with normal bone marrow. The study examined 93 children, including 78 Pre-B and 15 T-cell ALL patients. BMIS did not differ between the children with ALL and those with no evidence of cancer. BMIS was increased in 26.6% of patients at the end of the first year of treatment. Drug resistance and BM relapses were more prevalent in cases with high BMIS in both Pre-B and T-cell groups. Bone marrow iron store is not considered a risk factor for childhood ALL. However, high levels of BMIS are associated with poor response to treatment and the risk of relapse. Bone marrow iron store control during treatment can therefore help achieve better outcomes and improve the chances of recovery. |
format | Online Article Text |
id | pubmed-5682830 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-56828302017-11-28 The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia Moafi, Alireza Ziaie, Mozhdeh Abedi, Marjan Rahgozar, Soheila Reisi, Nahid Nematollahi, Pardis Moafi, Hadi Medicine (Baltimore) 5700 Iron is an intracellular element whose accumulation in the body is associated with tissue damage. This study examines the effect of iron on pediatric acute lymphoblastic leukemia (ALL) and its “response to treatment.” At the end of the first year of treatment, bone marrow iron store (BMIS) was evaluated in children with ALL and the relationship between iron store and minimal residual disease was investigated. Moreover, the 3-year disease-free survival (3-DFS) of patients was determined. Patients’ BMIS were compared with that of subjects with normal bone marrow. The study examined 93 children, including 78 Pre-B and 15 T-cell ALL patients. BMIS did not differ between the children with ALL and those with no evidence of cancer. BMIS was increased in 26.6% of patients at the end of the first year of treatment. Drug resistance and BM relapses were more prevalent in cases with high BMIS in both Pre-B and T-cell groups. Bone marrow iron store is not considered a risk factor for childhood ALL. However, high levels of BMIS are associated with poor response to treatment and the risk of relapse. Bone marrow iron store control during treatment can therefore help achieve better outcomes and improve the chances of recovery. Wolters Kluwer Health 2017-11-03 /pmc/articles/PMC5682830/ /pubmed/29095311 http://dx.doi.org/10.1097/MD.0000000000008511 Text en Copyright © 2017 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0 |
spellingShingle | 5700 Moafi, Alireza Ziaie, Mozhdeh Abedi, Marjan Rahgozar, Soheila Reisi, Nahid Nematollahi, Pardis Moafi, Hadi The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia |
title | The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia |
title_full | The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia |
title_fullStr | The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia |
title_full_unstemmed | The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia |
title_short | The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia |
title_sort | relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682830/ https://www.ncbi.nlm.nih.gov/pubmed/29095311 http://dx.doi.org/10.1097/MD.0000000000008511 |
work_keys_str_mv | AT moafialireza therelationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT ziaiemozhdeh therelationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT abedimarjan therelationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT rahgozarsoheila therelationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT reisinahid therelationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT nematollahipardis therelationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT moafihadi therelationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT moafialireza relationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT ziaiemozhdeh relationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT abedimarjan relationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT rahgozarsoheila relationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT reisinahid relationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT nematollahipardis relationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia AT moafihadi relationshipbetweenironbonemarrowstoresandresponsetotreatmentinpediatricacutelymphoblasticleukemia |