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Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults

PURPOSE: Berry-derived phenolic compounds found in grapes have been associated with a number of health benefits, including the augmentation of human brain function and cognition. Previous intervention studies of Concord grape juice have demonstrated improvement to memory and driving ability followin...

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Autores principales: Haskell-Ramsay, C. F., Stuart, R. C., Okello, E. J., Watson, A. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682870/
https://www.ncbi.nlm.nih.gov/pubmed/28429081
http://dx.doi.org/10.1007/s00394-017-1454-7
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author Haskell-Ramsay, C. F.
Stuart, R. C.
Okello, E. J.
Watson, A. W.
author_facet Haskell-Ramsay, C. F.
Stuart, R. C.
Okello, E. J.
Watson, A. W.
author_sort Haskell-Ramsay, C. F.
collection PubMed
description PURPOSE: Berry-derived phenolic compounds found in grapes have been associated with a number of health benefits, including the augmentation of human brain function and cognition. Previous intervention studies of Concord grape juice have demonstrated improvement to memory and driving ability following 3- to 4-month supplementation in middle-aged and older adults. However, no studies to date have demonstrated acute cognitive benefits of grape juice, and investigation of these effects in young adults is lacking. METHODS: This randomised, placebo-controlled, double-blind, counterbalanced-crossover study, assessed the effects of 230 ml purple grape juice or sugar-matched control in 20 healthy young adults. Computerised measures of episodic memory, working memory, attention and mood were completed at baseline and following a 20-min absorption period. RESULTS: Purple grape juice significantly improved reaction time on a composite attention measure (p = 0.047) and increased calm ratings (p = 0.046) when compared to placebo. Order effects also indicated an enduring positive effect on pre-dose memory reaction time (p = 0.018) and post-dose calm ratings (p = 0.019) when purple grape was consumed first. CONCLUSIONS: These findings in a small sample of healthy young adults suggest that purple grape juice can acutely enhance aspects of cognition and mood. No significant effects of juice were observed on memory measures, suggesting that these may be less susceptible to manipulation following acute supplementation in healthy young adults. Potential mechanisms underlying these effects include modulation of cerebral blood flow, glucoregulation and inhibition of monoamine oxidase activity, all of which require further exploration.
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spelling pubmed-56828702017-11-22 Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults Haskell-Ramsay, C. F. Stuart, R. C. Okello, E. J. Watson, A. W. Eur J Nutr Original Contribution PURPOSE: Berry-derived phenolic compounds found in grapes have been associated with a number of health benefits, including the augmentation of human brain function and cognition. Previous intervention studies of Concord grape juice have demonstrated improvement to memory and driving ability following 3- to 4-month supplementation in middle-aged and older adults. However, no studies to date have demonstrated acute cognitive benefits of grape juice, and investigation of these effects in young adults is lacking. METHODS: This randomised, placebo-controlled, double-blind, counterbalanced-crossover study, assessed the effects of 230 ml purple grape juice or sugar-matched control in 20 healthy young adults. Computerised measures of episodic memory, working memory, attention and mood were completed at baseline and following a 20-min absorption period. RESULTS: Purple grape juice significantly improved reaction time on a composite attention measure (p = 0.047) and increased calm ratings (p = 0.046) when compared to placebo. Order effects also indicated an enduring positive effect on pre-dose memory reaction time (p = 0.018) and post-dose calm ratings (p = 0.019) when purple grape was consumed first. CONCLUSIONS: These findings in a small sample of healthy young adults suggest that purple grape juice can acutely enhance aspects of cognition and mood. No significant effects of juice were observed on memory measures, suggesting that these may be less susceptible to manipulation following acute supplementation in healthy young adults. Potential mechanisms underlying these effects include modulation of cerebral blood flow, glucoregulation and inhibition of monoamine oxidase activity, all of which require further exploration. Springer Berlin Heidelberg 2017-04-20 2017 /pmc/articles/PMC5682870/ /pubmed/28429081 http://dx.doi.org/10.1007/s00394-017-1454-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Contribution
Haskell-Ramsay, C. F.
Stuart, R. C.
Okello, E. J.
Watson, A. W.
Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults
title Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults
title_full Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults
title_fullStr Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults
title_full_unstemmed Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults
title_short Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults
title_sort cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682870/
https://www.ncbi.nlm.nih.gov/pubmed/28429081
http://dx.doi.org/10.1007/s00394-017-1454-7
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