Molecular characterization of Panton-Valentine leukocidin (PVL) toxin–encoding phages from South India

A total of 19 methicillin-resistant Staphylococcus aureus (MRSA) isolates were investigated for Panton-Valentine leukocidin (PVL) toxin, PVL gene sequence variation and PVL-encoding phages. Whole genome sequencing was performed for all isolates. Analysis of MRSA isolates (n = 19) confirmed that most...

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Detalles Bibliográficos
Autores principales: Yamuna, D.B., Francis, Y.I., Priya Doss, G., Balaji, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
New Resistant Microbes in Human
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682882/
https://www.ncbi.nlm.nih.gov/pubmed/29158906
http://dx.doi.org/10.1016/j.nmni.2017.08.005
Descripción
Sumario:A total of 19 methicillin-resistant Staphylococcus aureus (MRSA) isolates were investigated for Panton-Valentine leukocidin (PVL) toxin, PVL gene sequence variation and PVL-encoding phages. Whole genome sequencing was performed for all isolates. Analysis of MRSA isolates (n = 19) confirmed that most MRSA (n = 11) were positive for the PVL gene and were multidrug resistant. ST772-MRSA-V was the predominant PVL-positive MRSA clone, although all of them were found to carry the ΦIND772PVL phage in the genome. This study provides insights into the evolution of a new lineage of PVL-MRSA and highlights the potential risk of the emergence of multidrug-resistant community-acquired MRSA with high virulence.

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