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Endoplasmic Reticulum Stress and Allergic Diseases
PURPOSE OF REVIEW: In this review, we will integrate recent knowledge on endoplasmic reticulum (ER) stress and allergy, thereby highlighting the therapeutic potential of ER stress in the context of precision medicine for allergic diseases. RECENT FINDINGS: Emerging evidence suggests that allergic di...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683051/ https://www.ncbi.nlm.nih.gov/pubmed/29119328 http://dx.doi.org/10.1007/s11882-017-0751-9 |
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author | Jeong, Jae Seok Kim, So Ri Cho, Seong Ho Lee, Yong Chul |
author_facet | Jeong, Jae Seok Kim, So Ri Cho, Seong Ho Lee, Yong Chul |
author_sort | Jeong, Jae Seok |
collection | PubMed |
description | PURPOSE OF REVIEW: In this review, we will integrate recent knowledge on endoplasmic reticulum (ER) stress and allergy, thereby highlighting the therapeutic potential of ER stress in the context of precision medicine for allergic diseases. RECENT FINDINGS: Emerging evidence suggests that allergic diseases are very heterogeneous having numerous endotypes. This leads to the new era of modern medicine, which assumes that a particular endotype-driven therapy, called precision medicine, would be more efficacious in a specific group of patients rather than in all patients. Currently, a dichotomy involving type 2/non-type 2 immune response underlies most of the studies on inflammatory and immunologic mechanisms of allergic disorders. Whereas there are several approved or investigational endotype-driven therapeutic agents targeting type 2 immune responses, investigation of mechanisms and endotype-driven interventions regarding non-type 2 immune response lags far behind. SUMMARY: Considering that non-type 2 immune response may represent a significant proportion of allergic disease, particularly corticosteroid-resistant severe disease, defining a novel concept of endotype-driven approach may be essential. Recently, stress responses originate from the endoplasmic reticulum (ER) and the associated inflammatory molecular platform has been suggested as a crucial player of immune and inflammatory responses. This implies that ER stress-related pathways may represent a new endotype-driven therapeutic strategy in the treatment of allergic diseases. |
format | Online Article Text |
id | pubmed-5683051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-56830512017-11-22 Endoplasmic Reticulum Stress and Allergic Diseases Jeong, Jae Seok Kim, So Ri Cho, Seong Ho Lee, Yong Chul Curr Allergy Asthma Rep Basic and Applied Science (I Lewkowich, Section Editor) PURPOSE OF REVIEW: In this review, we will integrate recent knowledge on endoplasmic reticulum (ER) stress and allergy, thereby highlighting the therapeutic potential of ER stress in the context of precision medicine for allergic diseases. RECENT FINDINGS: Emerging evidence suggests that allergic diseases are very heterogeneous having numerous endotypes. This leads to the new era of modern medicine, which assumes that a particular endotype-driven therapy, called precision medicine, would be more efficacious in a specific group of patients rather than in all patients. Currently, a dichotomy involving type 2/non-type 2 immune response underlies most of the studies on inflammatory and immunologic mechanisms of allergic disorders. Whereas there are several approved or investigational endotype-driven therapeutic agents targeting type 2 immune responses, investigation of mechanisms and endotype-driven interventions regarding non-type 2 immune response lags far behind. SUMMARY: Considering that non-type 2 immune response may represent a significant proportion of allergic disease, particularly corticosteroid-resistant severe disease, defining a novel concept of endotype-driven approach may be essential. Recently, stress responses originate from the endoplasmic reticulum (ER) and the associated inflammatory molecular platform has been suggested as a crucial player of immune and inflammatory responses. This implies that ER stress-related pathways may represent a new endotype-driven therapeutic strategy in the treatment of allergic diseases. Springer US 2017-11-08 2017 /pmc/articles/PMC5683051/ /pubmed/29119328 http://dx.doi.org/10.1007/s11882-017-0751-9 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Basic and Applied Science (I Lewkowich, Section Editor) Jeong, Jae Seok Kim, So Ri Cho, Seong Ho Lee, Yong Chul Endoplasmic Reticulum Stress and Allergic Diseases |
title | Endoplasmic Reticulum Stress and Allergic Diseases |
title_full | Endoplasmic Reticulum Stress and Allergic Diseases |
title_fullStr | Endoplasmic Reticulum Stress and Allergic Diseases |
title_full_unstemmed | Endoplasmic Reticulum Stress and Allergic Diseases |
title_short | Endoplasmic Reticulum Stress and Allergic Diseases |
title_sort | endoplasmic reticulum stress and allergic diseases |
topic | Basic and Applied Science (I Lewkowich, Section Editor) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683051/ https://www.ncbi.nlm.nih.gov/pubmed/29119328 http://dx.doi.org/10.1007/s11882-017-0751-9 |
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