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Current knowledge on psoriasis and autoimmune diseases

Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen presenting cells (APCs) and T cells. Exclusive cellular “responsibility” for the induction and maintenance of psoriatic pl...

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Autores principales: Ayala-Fontánez, Nilmarie, Soler, David C, McCormick, Thomas S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683130/
https://www.ncbi.nlm.nih.gov/pubmed/29387591
http://dx.doi.org/10.2147/PTT.S64950
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author Ayala-Fontánez, Nilmarie
Soler, David C
McCormick, Thomas S
author_facet Ayala-Fontánez, Nilmarie
Soler, David C
McCormick, Thomas S
author_sort Ayala-Fontánez, Nilmarie
collection PubMed
description Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen presenting cells (APCs) and T cells. Exclusive cellular “responsibility” for the induction and maintenance of psoriatic plaques has not been clearly defined. Increased proliferation of keratinocytes and endothelial cells in conjunction with APC/T cell/monocyte/macrophage inflammation leads to the distinct epidermal and vascular hyperplasia that is characteristic of lesional psoriatic skin. Despite the identification of numerous susceptibility loci, no single genetic determinant has been identified as responsible for the induction of psoriasis. Thus, numerous other triggers of disease, such as environmental, microbial and complex cellular interactions must also be considered as participants in the development of this multifactorial disease. Recent advances in therapeutics, especially systemic so-called “biologics” have provided new hope for identifying the critical cellular targets that drive psoriasis pathogenesis. Recent recognition of the numerous co-morbidities and other autoimmune disorders associated with psoriasis, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus suggest common signaling elements and cellular mediators may direct disease pathogenesis. In this review, we discuss common cellular pathways and participants that mediate psoriasis and other autoimmune disorders that share these cellular signaling pathways.
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spelling pubmed-56831302018-01-31 Current knowledge on psoriasis and autoimmune diseases Ayala-Fontánez, Nilmarie Soler, David C McCormick, Thomas S Psoriasis (Auckl) Review Psoriasis is a prevalent, chronic inflammatory disease of the skin, mediated by crosstalk between epidermal keratinocytes, dermal vascular cells, and immunocytes such as antigen presenting cells (APCs) and T cells. Exclusive cellular “responsibility” for the induction and maintenance of psoriatic plaques has not been clearly defined. Increased proliferation of keratinocytes and endothelial cells in conjunction with APC/T cell/monocyte/macrophage inflammation leads to the distinct epidermal and vascular hyperplasia that is characteristic of lesional psoriatic skin. Despite the identification of numerous susceptibility loci, no single genetic determinant has been identified as responsible for the induction of psoriasis. Thus, numerous other triggers of disease, such as environmental, microbial and complex cellular interactions must also be considered as participants in the development of this multifactorial disease. Recent advances in therapeutics, especially systemic so-called “biologics” have provided new hope for identifying the critical cellular targets that drive psoriasis pathogenesis. Recent recognition of the numerous co-morbidities and other autoimmune disorders associated with psoriasis, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus suggest common signaling elements and cellular mediators may direct disease pathogenesis. In this review, we discuss common cellular pathways and participants that mediate psoriasis and other autoimmune disorders that share these cellular signaling pathways. Dove Medical Press 2016-02-22 /pmc/articles/PMC5683130/ /pubmed/29387591 http://dx.doi.org/10.2147/PTT.S64950 Text en © 2016 Ayala-Fontánez et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Ayala-Fontánez, Nilmarie
Soler, David C
McCormick, Thomas S
Current knowledge on psoriasis and autoimmune diseases
title Current knowledge on psoriasis and autoimmune diseases
title_full Current knowledge on psoriasis and autoimmune diseases
title_fullStr Current knowledge on psoriasis and autoimmune diseases
title_full_unstemmed Current knowledge on psoriasis and autoimmune diseases
title_short Current knowledge on psoriasis and autoimmune diseases
title_sort current knowledge on psoriasis and autoimmune diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683130/
https://www.ncbi.nlm.nih.gov/pubmed/29387591
http://dx.doi.org/10.2147/PTT.S64950
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