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The cortical signature of impaired gesturing: Findings from schizophrenia

Schizophrenia is characterized by deficits in gesturing that is important for nonverbal communication. Research in healthy participants and brain-damaged patients revealed a left-lateralized fronto-parieto-temporal network underlying gesture performance. First evidence from structural imaging studie...

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Autores principales: Viher, Petra Verena, Stegmayer, Katharina, Kubicki, Marek, Karmacharya, Sarina, Lyall, Amanda Ellis, Federspiel, Andrea, Vanbellingen, Tim, Bohlhalter, Stephan, Wiest, Roland, Strik, Werner, Walther, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683189/
https://www.ncbi.nlm.nih.gov/pubmed/29159038
http://dx.doi.org/10.1016/j.nicl.2017.10.017
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author Viher, Petra Verena
Stegmayer, Katharina
Kubicki, Marek
Karmacharya, Sarina
Lyall, Amanda Ellis
Federspiel, Andrea
Vanbellingen, Tim
Bohlhalter, Stephan
Wiest, Roland
Strik, Werner
Walther, Sebastian
author_facet Viher, Petra Verena
Stegmayer, Katharina
Kubicki, Marek
Karmacharya, Sarina
Lyall, Amanda Ellis
Federspiel, Andrea
Vanbellingen, Tim
Bohlhalter, Stephan
Wiest, Roland
Strik, Werner
Walther, Sebastian
author_sort Viher, Petra Verena
collection PubMed
description Schizophrenia is characterized by deficits in gesturing that is important for nonverbal communication. Research in healthy participants and brain-damaged patients revealed a left-lateralized fronto-parieto-temporal network underlying gesture performance. First evidence from structural imaging studies in schizophrenia corroborates these results. However, as of yet, it is unclear if cortical thickness abnormalities contribute to impairments in gesture performance. We hypothesized that patients with deficits in gesture production show cortical thinning in 12 regions of interest (ROIs) of a gesture network relevant for gesture performance and recognition. Forty patients with schizophrenia and 41 healthy controls performed hand and finger gestures as either imitation or pantomime. Group differences in cortical thickness between patients with deficits, patients without deficits, and controls were explored using a multivariate analysis of covariance. In addition, the relationship between gesture recognition and cortical thickness was investigated. Patients with deficits in gesture production had reduced cortical thickness in eight ROIs, including the pars opercularis of the inferior frontal gyrus, the superior and inferior parietal lobes, and the superior and middle temporal gyri. Gesture recognition correlated with cortical thickness in fewer, but mainly the same, ROIs within the patient sample. In conclusion, our results show that impaired gesture production and recognition in schizophrenia is associated with cortical thinning in distinct areas of the gesture network.
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spelling pubmed-56831892017-11-20 The cortical signature of impaired gesturing: Findings from schizophrenia Viher, Petra Verena Stegmayer, Katharina Kubicki, Marek Karmacharya, Sarina Lyall, Amanda Ellis Federspiel, Andrea Vanbellingen, Tim Bohlhalter, Stephan Wiest, Roland Strik, Werner Walther, Sebastian Neuroimage Clin Regular Article Schizophrenia is characterized by deficits in gesturing that is important for nonverbal communication. Research in healthy participants and brain-damaged patients revealed a left-lateralized fronto-parieto-temporal network underlying gesture performance. First evidence from structural imaging studies in schizophrenia corroborates these results. However, as of yet, it is unclear if cortical thickness abnormalities contribute to impairments in gesture performance. We hypothesized that patients with deficits in gesture production show cortical thinning in 12 regions of interest (ROIs) of a gesture network relevant for gesture performance and recognition. Forty patients with schizophrenia and 41 healthy controls performed hand and finger gestures as either imitation or pantomime. Group differences in cortical thickness between patients with deficits, patients without deficits, and controls were explored using a multivariate analysis of covariance. In addition, the relationship between gesture recognition and cortical thickness was investigated. Patients with deficits in gesture production had reduced cortical thickness in eight ROIs, including the pars opercularis of the inferior frontal gyrus, the superior and inferior parietal lobes, and the superior and middle temporal gyri. Gesture recognition correlated with cortical thickness in fewer, but mainly the same, ROIs within the patient sample. In conclusion, our results show that impaired gesture production and recognition in schizophrenia is associated with cortical thinning in distinct areas of the gesture network. Elsevier 2017-10-18 /pmc/articles/PMC5683189/ /pubmed/29159038 http://dx.doi.org/10.1016/j.nicl.2017.10.017 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Viher, Petra Verena
Stegmayer, Katharina
Kubicki, Marek
Karmacharya, Sarina
Lyall, Amanda Ellis
Federspiel, Andrea
Vanbellingen, Tim
Bohlhalter, Stephan
Wiest, Roland
Strik, Werner
Walther, Sebastian
The cortical signature of impaired gesturing: Findings from schizophrenia
title The cortical signature of impaired gesturing: Findings from schizophrenia
title_full The cortical signature of impaired gesturing: Findings from schizophrenia
title_fullStr The cortical signature of impaired gesturing: Findings from schizophrenia
title_full_unstemmed The cortical signature of impaired gesturing: Findings from schizophrenia
title_short The cortical signature of impaired gesturing: Findings from schizophrenia
title_sort cortical signature of impaired gesturing: findings from schizophrenia
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683189/
https://www.ncbi.nlm.nih.gov/pubmed/29159038
http://dx.doi.org/10.1016/j.nicl.2017.10.017
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