Prospects for using risk scores in polygenic medicine

Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of co...

Descripción completa

Detalles Bibliográficos
Autores principales: Lewis, Cathryn M., Vassos, Evangelos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683372/
https://www.ncbi.nlm.nih.gov/pubmed/29132412
http://dx.doi.org/10.1186/s13073-017-0489-y
_version_ 1783278272081035264
author Lewis, Cathryn M.
Vassos, Evangelos
author_facet Lewis, Cathryn M.
Vassos, Evangelos
author_sort Lewis, Cathryn M.
collection PubMed
description Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of complex traits and diseases, including neuropsychiatric disorders. Here, we consider the potential for translation to clinical use.
format Online
Article
Text
id pubmed-5683372
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-56833722017-11-20 Prospects for using risk scores in polygenic medicine Lewis, Cathryn M. Vassos, Evangelos Genome Med Comment Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of complex traits and diseases, including neuropsychiatric disorders. Here, we consider the potential for translation to clinical use. BioMed Central 2017-11-13 /pmc/articles/PMC5683372/ /pubmed/29132412 http://dx.doi.org/10.1186/s13073-017-0489-y Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Lewis, Cathryn M.
Vassos, Evangelos
Prospects for using risk scores in polygenic medicine
title Prospects for using risk scores in polygenic medicine
title_full Prospects for using risk scores in polygenic medicine
title_fullStr Prospects for using risk scores in polygenic medicine
title_full_unstemmed Prospects for using risk scores in polygenic medicine
title_short Prospects for using risk scores in polygenic medicine
title_sort prospects for using risk scores in polygenic medicine
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683372/
https://www.ncbi.nlm.nih.gov/pubmed/29132412
http://dx.doi.org/10.1186/s13073-017-0489-y
work_keys_str_mv AT lewiscathrynm prospectsforusingriskscoresinpolygenicmedicine
AT vassosevangelos prospectsforusingriskscoresinpolygenicmedicine

Ejemplares similares