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Prospects for using risk scores in polygenic medicine
Genome-wide association studies have made strides in identifying common variation associated with disease. The modest effect sizes preclude risk prediction based on single genetic variants, but polygenic risk scores that combine thousands of variants show some predictive ability across a range of co...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683372/ https://www.ncbi.nlm.nih.gov/pubmed/29132412 http://dx.doi.org/10.1186/s13073-017-0489-y |