Optimized approach for the identification of highly efficient correctors of nonsense mutations in human diseases

About 10% of patients with a genetic disease carry a nonsense mutation causing their pathology. A strategy for correcting nonsense mutations is premature termination codon (PTC) readthrough, i.e. incorporation of an amino acid at the PTC position during translation. PTC-readthrough-activating molecu...

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Detalles Bibliográficos
Autores principales: Benhabiles, Hana, Gonzalez-Hilarion, Sara, Amand, Séverine, Bailly, Christine, Prévotat, Anne, Reix, Philippe, Hubert, Dominique, Adriaenssens, Eric, Rebuffat, Sylvie, Tulasne, David, Lejeune, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683606/
https://www.ncbi.nlm.nih.gov/pubmed/29131862
http://dx.doi.org/10.1371/journal.pone.0187930

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