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Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury

OBJECTIVE: The aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum, and to evaluate the effects of different interventions. METHODS: A 7 mm-diameter circular mucosal defect was made in the septum of fo...

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Autores principales: Choi, Kyu Young, Cho, Sung Woo, Choi, Jun-Jae, Zhang, Yu-Lian, Kim, Dae Woo, Han, Doo Hee, Kim, Hyun Jik, Kim, Dong-Young, Rhee, Chae-Seo, Won, Tae-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683622/
https://www.ncbi.nlm.nih.gov/pubmed/29204575
http://dx.doi.org/10.1016/j.wjorl.2017.02.004
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author Choi, Kyu Young
Cho, Sung Woo
Choi, Jun-Jae
Zhang, Yu-Lian
Kim, Dae Woo
Han, Doo Hee
Kim, Hyun Jik
Kim, Dong-Young
Rhee, Chae-Seo
Won, Tae-Bin
author_facet Choi, Kyu Young
Cho, Sung Woo
Choi, Jun-Jae
Zhang, Yu-Lian
Kim, Dae Woo
Han, Doo Hee
Kim, Hyun Jik
Kim, Dong-Young
Rhee, Chae-Seo
Won, Tae-Bin
author_sort Choi, Kyu Young
collection PubMed
description OBJECTIVE: The aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum, and to evaluate the effects of different interventions. METHODS: A 7 mm-diameter circular mucosal defect was made in the septum of forty New Zealand white rabbits. The rabbits were divided into four groups (ten rabbits in each group) according to the type of intervention; no treatment (control), silastic sheet (SS), hyaluronic acid (HA), and silastic sheet and hyaluronic acid (SS + HA) group. The diameter of the defect, mucosal thickness, epithelial thickness, and ciliated cell count were evaluated every week for five weeks. RESULTS: The average diameter of the defect in the control group were 5.1, 3.65, 1.2, 0.75, and 0.05 mm at postoperative 1, 2, 3, 4, and 5 weeks. In the SS group, the diameter decreased to 4.35, 2.1, 0.35, 0.15, and 0 mm at postoperative 1, 2, 3, 4, and 5 weeks, respectively, in which the mean diameter of the postoperative week 2 was significantly smaller compared to control (3.65 mm vs. 2.1 mm, P = 0.039). For the HA group and SS + HA group, the diameter of the defect did not show a significant difference from the control group during the five weeks. The mucosal thickness, epithelial thickness, and ciliated cell count of the regenerated mucosa were not significantly different among the groups. CONCLUSION: The regeneration process of the nasal septal mucosa was identified using a novel rabbit model. Mucosal regeneration can be accelerated by applying silastic sheets.
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spelling pubmed-56836222017-12-04 Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury Choi, Kyu Young Cho, Sung Woo Choi, Jun-Jae Zhang, Yu-Lian Kim, Dae Woo Han, Doo Hee Kim, Hyun Jik Kim, Dong-Young Rhee, Chae-Seo Won, Tae-Bin World J Otorhinolaryngol Head Neck Surg Research Paper OBJECTIVE: The aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum, and to evaluate the effects of different interventions. METHODS: A 7 mm-diameter circular mucosal defect was made in the septum of forty New Zealand white rabbits. The rabbits were divided into four groups (ten rabbits in each group) according to the type of intervention; no treatment (control), silastic sheet (SS), hyaluronic acid (HA), and silastic sheet and hyaluronic acid (SS + HA) group. The diameter of the defect, mucosal thickness, epithelial thickness, and ciliated cell count were evaluated every week for five weeks. RESULTS: The average diameter of the defect in the control group were 5.1, 3.65, 1.2, 0.75, and 0.05 mm at postoperative 1, 2, 3, 4, and 5 weeks. In the SS group, the diameter decreased to 4.35, 2.1, 0.35, 0.15, and 0 mm at postoperative 1, 2, 3, 4, and 5 weeks, respectively, in which the mean diameter of the postoperative week 2 was significantly smaller compared to control (3.65 mm vs. 2.1 mm, P = 0.039). For the HA group and SS + HA group, the diameter of the defect did not show a significant difference from the control group during the five weeks. The mucosal thickness, epithelial thickness, and ciliated cell count of the regenerated mucosa were not significantly different among the groups. CONCLUSION: The regeneration process of the nasal septal mucosa was identified using a novel rabbit model. Mucosal regeneration can be accelerated by applying silastic sheets. KeAi Publishing 2017-03-09 /pmc/articles/PMC5683622/ /pubmed/29204575 http://dx.doi.org/10.1016/j.wjorl.2017.02.004 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Choi, Kyu Young
Cho, Sung Woo
Choi, Jun-Jae
Zhang, Yu-Lian
Kim, Dae Woo
Han, Doo Hee
Kim, Hyun Jik
Kim, Dong-Young
Rhee, Chae-Seo
Won, Tae-Bin
Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury
title Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury
title_full Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury
title_fullStr Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury
title_full_unstemmed Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury
title_short Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury
title_sort healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683622/
https://www.ncbi.nlm.nih.gov/pubmed/29204575
http://dx.doi.org/10.1016/j.wjorl.2017.02.004
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