MEK inhibitors enhance therapeutic response towards ATRA in NF1 associated malignant peripheral nerve sheath tumors (MPNST) in-vitro

OBJECTIVE: Neurofibromatosis type 1 (NF1) is a hereditary tumor syndrome characterized by an increased risk of malignant peripheral nerve sheath tumors (MPNST). Chemotherapy of MPNST is still insufficient. In this study, we investigated whether human tumor Schwann cells derived from NF1 associated M...

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Detalles Bibliográficos
Autores principales: Fischer-Huchzermeyer, Susan, Dombrowski, Anna, Wilke, Gordon, Stahn, Verena, Streubel, Anna, Mautner, Victor Felix, Harder, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683628/
https://www.ncbi.nlm.nih.gov/pubmed/29131833
http://dx.doi.org/10.1371/journal.pone.0187700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683628/
https://www.ncbi.nlm.nih.gov/pubmed/29131833
http://dx.doi.org/10.1371/journal.pone.0187700

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