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Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure
High dose manganese (Mn) exposure can result in changes in tissue concentrations of other essential metals due to Mn-induced alterations in metal absorption and competition for metal transporters and regulatory proteins. We evaluated responses in mice with a Parkin gene defect (parkin mice) and a wi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683753/ https://www.ncbi.nlm.nih.gov/pubmed/29159229 http://dx.doi.org/10.1016/j.dib.2017.10.050 |
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author | Foster, Melanie L. Bartnikas, Thomas B. Maresca-Fichter, Hailey C. Mercadante, Courtney Dash, Miriam Miller, Chelsea Dorman, David C. |
author_facet | Foster, Melanie L. Bartnikas, Thomas B. Maresca-Fichter, Hailey C. Mercadante, Courtney Dash, Miriam Miller, Chelsea Dorman, David C. |
author_sort | Foster, Melanie L. |
collection | PubMed |
description | High dose manganese (Mn) exposure can result in changes in tissue concentrations of other essential metals due to Mn-induced alterations in metal absorption and competition for metal transporters and regulatory proteins. We evaluated responses in mice with a Parkin gene defect (parkin mice) and a wildtype strain (C57BL/6J) following neonatal Mn exposure. Neonatal parkin and C57BL/6J littermates were randomly assigned to 0, 11, or 25 mg Mn/kg-day dose groups with oral exposures occurring from postnatal day (PND) 1 through PND 28. We report liver, femur, olfactory bulb, striatum, and frontal cortex iron, copper, and zinc concentrations and changes in hepatic gene expression of different metal transporters in PND 29 parkin and C57BL/6J mice. A companion manuscript (Foster et al., 2017) [1] describes the primary study findings. This data provides insights into strain differences in the way Mn interacts with other trace metals in mice. |
format | Online Article Text |
id | pubmed-5683753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-56837532017-11-20 Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure Foster, Melanie L. Bartnikas, Thomas B. Maresca-Fichter, Hailey C. Mercadante, Courtney Dash, Miriam Miller, Chelsea Dorman, David C. Data Brief Neurosciences High dose manganese (Mn) exposure can result in changes in tissue concentrations of other essential metals due to Mn-induced alterations in metal absorption and competition for metal transporters and regulatory proteins. We evaluated responses in mice with a Parkin gene defect (parkin mice) and a wildtype strain (C57BL/6J) following neonatal Mn exposure. Neonatal parkin and C57BL/6J littermates were randomly assigned to 0, 11, or 25 mg Mn/kg-day dose groups with oral exposures occurring from postnatal day (PND) 1 through PND 28. We report liver, femur, olfactory bulb, striatum, and frontal cortex iron, copper, and zinc concentrations and changes in hepatic gene expression of different metal transporters in PND 29 parkin and C57BL/6J mice. A companion manuscript (Foster et al., 2017) [1] describes the primary study findings. This data provides insights into strain differences in the way Mn interacts with other trace metals in mice. Elsevier 2017-10-24 /pmc/articles/PMC5683753/ /pubmed/29159229 http://dx.doi.org/10.1016/j.dib.2017.10.050 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Neurosciences Foster, Melanie L. Bartnikas, Thomas B. Maresca-Fichter, Hailey C. Mercadante, Courtney Dash, Miriam Miller, Chelsea Dorman, David C. Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure |
title | Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure |
title_full | Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure |
title_fullStr | Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure |
title_full_unstemmed | Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure |
title_short | Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure |
title_sort | interactions of manganese with iron, zinc, and copper in neonatal c57bl/6j and parkin mice following developmental oral manganese exposure |
topic | Neurosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683753/ https://www.ncbi.nlm.nih.gov/pubmed/29159229 http://dx.doi.org/10.1016/j.dib.2017.10.050 |
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