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Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure
MIC60/mitofilin constitutes a hetero-oligomeric complex on the inner mitochondrial membranes to maintain crista structure. However, little is known about its physiological functions. Here, by characterizing Drosophila MIC60 mutants, we define its roles in vivo. We discover that MIC60 performs dual f...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683758/ https://www.ncbi.nlm.nih.gov/pubmed/28904209 http://dx.doi.org/10.1091/mbc.E17-03-0177 |
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author | Tsai, Pei-I Papakyrikos, Amanda M. Hsieh, Chung-Han Wang, Xinnan |
author_facet | Tsai, Pei-I Papakyrikos, Amanda M. Hsieh, Chung-Han Wang, Xinnan |
author_sort | Tsai, Pei-I |
collection | PubMed |
description | MIC60/mitofilin constitutes a hetero-oligomeric complex on the inner mitochondrial membranes to maintain crista structure. However, little is known about its physiological functions. Here, by characterizing Drosophila MIC60 mutants, we define its roles in vivo. We discover that MIC60 performs dual functions to maintain mitochondrial homeostasis. In addition to its canonical role in crista membrane structure, MIC60 regulates mitochondrial motility, likely by influencing protein levels of the outer mitochondrial membrane protein Miro that anchors mitochondria to the microtubule motors. Loss of MIC60 causes loss of Miro and mitochondrial arrest. At a cellular level, loss of MIC60 disrupts synaptic structure and function at the neuromuscular junctions. The dual roles of MIC60 in both mitochondrial crista structure and motility position it as a crucial player for cellular integrity and survival. |
format | Online Article Text |
id | pubmed-5683758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-56837582018-01-30 Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure Tsai, Pei-I Papakyrikos, Amanda M. Hsieh, Chung-Han Wang, Xinnan Mol Biol Cell Brief Reports MIC60/mitofilin constitutes a hetero-oligomeric complex on the inner mitochondrial membranes to maintain crista structure. However, little is known about its physiological functions. Here, by characterizing Drosophila MIC60 mutants, we define its roles in vivo. We discover that MIC60 performs dual functions to maintain mitochondrial homeostasis. In addition to its canonical role in crista membrane structure, MIC60 regulates mitochondrial motility, likely by influencing protein levels of the outer mitochondrial membrane protein Miro that anchors mitochondria to the microtubule motors. Loss of MIC60 causes loss of Miro and mitochondrial arrest. At a cellular level, loss of MIC60 disrupts synaptic structure and function at the neuromuscular junctions. The dual roles of MIC60 in both mitochondrial crista structure and motility position it as a crucial player for cellular integrity and survival. The American Society for Cell Biology 2017-11-15 /pmc/articles/PMC5683758/ /pubmed/28904209 http://dx.doi.org/10.1091/mbc.E17-03-0177 Text en © 2017 Tsai, Papakyrikos, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology. |
spellingShingle | Brief Reports Tsai, Pei-I Papakyrikos, Amanda M. Hsieh, Chung-Han Wang, Xinnan Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure |
title | Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure |
title_full | Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure |
title_fullStr | Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure |
title_full_unstemmed | Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure |
title_short | Drosophila MIC60/mitofilin conducts dual roles in mitochondrial motility and crista structure |
title_sort | drosophila mic60/mitofilin conducts dual roles in mitochondrial motility and crista structure |
topic | Brief Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683758/ https://www.ncbi.nlm.nih.gov/pubmed/28904209 http://dx.doi.org/10.1091/mbc.E17-03-0177 |
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