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Dead cell phagocytosis and innate immune checkpoint

The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mecha...

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Autor principal: Yoon, Kyoung Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683818/
https://www.ncbi.nlm.nih.gov/pubmed/28768566
http://dx.doi.org/10.5483/BMBRep.2017.50.10.147
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author Yoon, Kyoung Wan
author_facet Yoon, Kyoung Wan
author_sort Yoon, Kyoung Wan
collection PubMed
description The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations.
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spelling pubmed-56838182017-11-21 Dead cell phagocytosis and innate immune checkpoint Yoon, Kyoung Wan BMB Rep Invited Mini Review The human body loses several billions of cells daily. When cells die in vivo, the corpse of each dead cell is immediately cleared. Specifically, dead cells are efficiently recognized and cleared by multiple types of neighboring phagocytes. Early research on cell death focused more on molecular mechanisms of cell death regulation while the cellular corpses were merely considered cellular debris. However, it has come to light that various biological stimuli following cell death are important for immune regulation. Clearance of normal dead cells occurs silently in immune tolerance. Exogenous or mutated antigens of malignant or infected cells can initiate adaptive immunity, thereby inducing immunogenicity by adjuvant signals. Several pathogens and cancer cells have strategies to limit the adjuvant signals and escape immune surveillance. In this review, we present an overview of the mechanisms of dead cell clearance and its immune regulations. Korean Society for Biochemistry and Molecular Biology 2017-10 2017-10-31 /pmc/articles/PMC5683818/ /pubmed/28768566 http://dx.doi.org/10.5483/BMBRep.2017.50.10.147 Text en Copyright © 2017 by the The Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Mini Review
Yoon, Kyoung Wan
Dead cell phagocytosis and innate immune checkpoint
title Dead cell phagocytosis and innate immune checkpoint
title_full Dead cell phagocytosis and innate immune checkpoint
title_fullStr Dead cell phagocytosis and innate immune checkpoint
title_full_unstemmed Dead cell phagocytosis and innate immune checkpoint
title_short Dead cell phagocytosis and innate immune checkpoint
title_sort dead cell phagocytosis and innate immune checkpoint
topic Invited Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5683818/
https://www.ncbi.nlm.nih.gov/pubmed/28768566
http://dx.doi.org/10.5483/BMBRep.2017.50.10.147
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