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Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients

Xanthine oxidoreductase activity (XOR-a) plays an important role as a pivotal source of reactive oxygen species. In the present study, we investigated factors associated with plasma XOR-a in 163 hemodialysis patients (age 67.3 ± 10.9 years; 89 males and 74 females), using a newly established, highly...

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Autores principales: Nakatani, Ayumi, Nakatani, Shinya, Ishimura, Eiji, Murase, Takayo, Nakamura, Takashi, Sakura, Mari, Tateishi, Yu, Tsuda, Akihiro, Kurajoh, Masafumi, Mori, Katsuhito, Emoto, Masanori, Inaba, Masaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684129/
https://www.ncbi.nlm.nih.gov/pubmed/29133805
http://dx.doi.org/10.1038/s41598-017-15419-0
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author Nakatani, Ayumi
Nakatani, Shinya
Ishimura, Eiji
Murase, Takayo
Nakamura, Takashi
Sakura, Mari
Tateishi, Yu
Tsuda, Akihiro
Kurajoh, Masafumi
Mori, Katsuhito
Emoto, Masanori
Inaba, Masaaki
author_facet Nakatani, Ayumi
Nakatani, Shinya
Ishimura, Eiji
Murase, Takayo
Nakamura, Takashi
Sakura, Mari
Tateishi, Yu
Tsuda, Akihiro
Kurajoh, Masafumi
Mori, Katsuhito
Emoto, Masanori
Inaba, Masaaki
author_sort Nakatani, Ayumi
collection PubMed
description Xanthine oxidoreductase activity (XOR-a) plays an important role as a pivotal source of reactive oxygen species. In the present study, we investigated factors associated with plasma XOR-a in 163 hemodialysis patients (age 67.3 ± 10.9 years; 89 males and 74 females), using a newly established, highly-sensitive assay based on [(13)C(2),(15)N(2)] xanthine and liquid chromatography/triple quadrupole mass spectrometry. Plasma glucose and serum uric acid levels correlated significantly and positively with plasma XOR-a. In multiple regression analyses, the presence of type 2 diabetes mellitus (T2DM) and plasma glucose were associated significantly, independently, and positively with plasma XOR-a. While serum uric acid correlated significantly and positively with plasma XOR-a in hemodialysis patients without T2DM, plasma glucose and serum glycated albumin, a new marker of glycemic control in diabetic hemodialysis patients, correlated significantly and positively with plasma XOR-a in those with T2DM. Multivariate analyses in those with T2DM revealed that plasma glucose and serum glycated albumin were associated significantly and independently with plasma XOR-a, and that serum uric acid was associated significantly and independently with XOR-a in those without T2DM. Our results suggested that glycemic control in hemodialysis patients may be important in regard to a decrease in ROS induced by XOR.
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spelling pubmed-56841292017-11-21 Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients Nakatani, Ayumi Nakatani, Shinya Ishimura, Eiji Murase, Takayo Nakamura, Takashi Sakura, Mari Tateishi, Yu Tsuda, Akihiro Kurajoh, Masafumi Mori, Katsuhito Emoto, Masanori Inaba, Masaaki Sci Rep Article Xanthine oxidoreductase activity (XOR-a) plays an important role as a pivotal source of reactive oxygen species. In the present study, we investigated factors associated with plasma XOR-a in 163 hemodialysis patients (age 67.3 ± 10.9 years; 89 males and 74 females), using a newly established, highly-sensitive assay based on [(13)C(2),(15)N(2)] xanthine and liquid chromatography/triple quadrupole mass spectrometry. Plasma glucose and serum uric acid levels correlated significantly and positively with plasma XOR-a. In multiple regression analyses, the presence of type 2 diabetes mellitus (T2DM) and plasma glucose were associated significantly, independently, and positively with plasma XOR-a. While serum uric acid correlated significantly and positively with plasma XOR-a in hemodialysis patients without T2DM, plasma glucose and serum glycated albumin, a new marker of glycemic control in diabetic hemodialysis patients, correlated significantly and positively with plasma XOR-a in those with T2DM. Multivariate analyses in those with T2DM revealed that plasma glucose and serum glycated albumin were associated significantly and independently with plasma XOR-a, and that serum uric acid was associated significantly and independently with XOR-a in those without T2DM. Our results suggested that glycemic control in hemodialysis patients may be important in regard to a decrease in ROS induced by XOR. Nature Publishing Group UK 2017-11-13 /pmc/articles/PMC5684129/ /pubmed/29133805 http://dx.doi.org/10.1038/s41598-017-15419-0 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Nakatani, Ayumi
Nakatani, Shinya
Ishimura, Eiji
Murase, Takayo
Nakamura, Takashi
Sakura, Mari
Tateishi, Yu
Tsuda, Akihiro
Kurajoh, Masafumi
Mori, Katsuhito
Emoto, Masanori
Inaba, Masaaki
Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients
title Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients
title_full Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients
title_fullStr Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients
title_full_unstemmed Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients
title_short Xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients
title_sort xanthine oxidoreductase activity is associated with serum uric acid and glycemic control in hemodialysis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684129/
https://www.ncbi.nlm.nih.gov/pubmed/29133805
http://dx.doi.org/10.1038/s41598-017-15419-0
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