Nitric oxide mediated inhibition of antigen presentation from DCs to CD4(+) T cells in cancer and measurement of STAT1 nitration

Myeloid derived suppressor cells (MDSC) produce nitric oxide (NO) and inhibit dendritic cell (DC) immune responses in cancer. DCs present cancer cell antigens to CD4(+) T cells through Jak-STAT signal transduction. In this study, NO donors (SNAP and DETA-NONOate) inhibited DC antigen presentation. A...

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Detalles Bibliográficos
Autores principales: Markowitz, Joseph, Wang, Jiang, Vangundy, Zach, You, Jia, Yildiz, Vedat, Yu, Lianbo, Foote, Isaac P., Branson, Owen E., Stiff, Andrew R., Brooks, Taylor R., Biesiadecki, Brandon, Olencki, Thomas, Tridandapani, Susheela, Freitas, Michael A., Papenfuss, Tracey, Phelps, Mitch A., Carson, William E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684213/
https://www.ncbi.nlm.nih.gov/pubmed/29133913
http://dx.doi.org/10.1038/s41598-017-14970-0

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