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The six metal binding domains in human copper transporter, ATP7B: molecular biophysics and disease-causing mutations
Wilson Disease (WD) is a hereditary genetic disorder, which coincides with a dysfunctional copper (Cu) metabolism caused by mutations in ATP7B, a membrane-bound P(1B)-type ATPase responsible for Cu export from hepatic cells. The N-terminal part (~ 600 residues) of the multi-domain 1400-residue ATP7B...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684295/ https://www.ncbi.nlm.nih.gov/pubmed/29063292 http://dx.doi.org/10.1007/s10534-017-0058-2 |