ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

Endoplasmic-reticulum-associated degradation (ERAD) is an important protein quality control system which maintains protein homeostasis. Constituents of the ERAD complex and its role in neurodegeneration are not yet fully understood. Here, using proteomic and FRET analyses, we demonstrate that the ER...

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Detalles Bibliográficos
Autores principales: Zhu, Bing, Jiang, LuLin, Huang, Timothy, Zhao, Yingjun, Liu, Tongfei, Zhong, Yongwang, Li, Xiaoguang, Campos, Alexandre, Pomeroy, Kenneth, Masliah, Eliezer, Zhang, Dongxian, Xu, Huaxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684335/
https://www.ncbi.nlm.nih.gov/pubmed/29133892
http://dx.doi.org/10.1038/s41467-017-01799-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684335/
https://www.ncbi.nlm.nih.gov/pubmed/29133892
http://dx.doi.org/10.1038/s41467-017-01799-4

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