Cargando…

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

Endoplasmic-reticulum-associated degradation (ERAD) is an important protein quality control system which maintains protein homeostasis. Constituents of the ERAD complex and its role in neurodegeneration are not yet fully understood. Here, using proteomic and FRET analyses, we demonstrate that the ER...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Bing, Jiang, LuLin, Huang, Timothy, Zhao, Yingjun, Liu, Tongfei, Zhong, Yongwang, Li, Xiaoguang, Campos, Alexandre, Pomeroy, Kenneth, Masliah, Eliezer, Zhang, Dongxian, Xu, Huaxi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684335/ https://www.ncbi.nlm.nih.gov/pubmed/29133892 http://dx.doi.org/10.1038/s41467-017-01799-4

Ejemplares similares

γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022)

The γ-secretase complex: from structure to function
por: Zhang, Xian, et al.
Publicado: (2014)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex
por: Cai, Zhiyou, et al.
Publicado: (2015)

Innate immunity protein IFITM3 modulates γ-secretase in Alzheimer disease
por: Hur, Ji-Yeun, et al.
Publicado: (2020)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
por: Bolduc, David M, et al.
Publicado: (2016)

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
por: Chávez-Gutiérrez, Lucía, et al.
Publicado: (2012)

Turning the tide on Alzheimer’s disease: modulation of γ-secretase
por: Luo, Joanna E., et al.
Publicado: (2022)

Interplay between α-, β-, and γ-Secretases Determines Biphasic Amyloid-β Protein Level in the Presence of a γ-Secretase Inhibitor
por: Ortega, Fernando, et al.
Publicado: (2013)

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
por: Lessard, Christian B., et al.
Publicado: (2015)

Substrate interaction inhibits γ-secretase production of amyloid-β peptides
por: Zhao, Jing, et al.
Publicado: (2020)

Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease
por: Pluta, Ryszard, et al.
Publicado: (2012)

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis
por: Cui, Jin, et al.
Publicado: (2015)

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein
por: Do, Hung N., et al.
Publicado: (2023)

Familial Alzheimer’s disease mutations in amyloid protein precursor alter proteolysis by γ-secretase to increase amyloid β-peptides of ≥45 residues
por: Devkota, Sujan, et al.
Publicado: (2021)

SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration
por: Huang, Timothy Y., et al.
Publicado: (2017)

γ-Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?
por: Toyn, Jeremy H., et al.
Publicado: (2013)

BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer’s Disease
por: Maia, Miguel A., et al.
Publicado: (2019)

A promising new γ-secretase modulator for Alzheimer’s disease
por: Dobrowolska Zakaria, Justyna A., et al.
Publicado: (2021)

Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease
por: Wolfe, Michael S.
Publicado: (2021)

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate
por: Ho, Michael, et al.
Publicado: (2010)

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
por: Steiner, Harald, et al.
Publicado: (2018)

A thermodynamic investigation of amyloid precursor protein processing by human γ-secretase
por: Lu, Xiaoli, et al.
Publicado: (2022)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010)

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels
por: Schedin-Weiss, Sophia, et al.
Publicado: (2017)

Phenotypic analysis of images of zebrafish treated with Alzheimer's γ-secretase inhibitors
por: Arslanova, Dilyara, et al.
Publicado: (2010)

Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease
por: Kakuda, Nobuto, et al.
Publicado: (2012)

Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer’s disease
por: Doody, Rachelle S, et al.
Publicado: (2015)

Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
por: Szaruga, Maria, et al.
Publicado: (2015)

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease
por: MacLeod, Ruth, et al.
Publicado: (2015)

Inactivation of γ‐secretases leads to accumulation of substrates and non‐Alzheimer neurodegeneration
por: Acx, Hermien, et al.
Publicado: (2017)

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics
por: Mouchlis, Varnavas D., et al.
Publicado: (2020)

The discrepancy between presenilin subcellular localization and γ-secretase processing of amyloid precursor protein
por: Cupers, Philippe, et al.
Publicado: (2001)

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity
por: Jung, Joo In, et al.
Publicado: (2014)

ABCG1 and ABCG4 Suppress γ-Secretase Activity and Amyloid β Production
por: Sano, Osamu, et al.
Publicado: (2016)

Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010)

The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation
por: Hu, Jin, et al.
Publicado: (2015)

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease
por: Basi, Guriqbal S, et al.
Publicado: (2010)

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease
por: Zhang, Zhentao, et al.
Publicado: (2015)

Structural and Functional Determinants of γ-Secretase, an Intramembrane Protease Implicated in Alzheimer’s Disease
por: Fraering, Patrick C
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_grr2a460coda2gpcobmiu2rv7m