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Essential role of mitochondrial Stat3 in p38(MAPK) mediated apoptosis under oxidative stress

Stat3 is an oncogene, frequently associated with malignant transformation. A body of evidence implicates that phospho-Stat3(Y705) contributes to its nucleic translocation, while phospho-Stat3(S727) leads to the accumulation in mitochondria. Both are of importance for tumor cell proliferation. In com...

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Detalles Bibliográficos
Autores principales:	Cheng, Xinlai, Peuckert, Christiane, Wölfl, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684365/ https://www.ncbi.nlm.nih.gov/pubmed/29133922 http://dx.doi.org/10.1038/s41598-017-15342-4

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