Cargando…

Antidiabetic and Antidyslipidemic Activities of the Aqueous Extract of Cochlospermum planchonii Leaves in Streptozotocin-Induced Diabetic Rats

BACKGROUND: Diabetes mellitus is considered one of the 5 principal causes of death in the world and is recognized as a global public health issue because of its multifactorial facets affecting essential biochemical processes in the body. This study investigated the antidiabetic and antidyslipidemic...

Descripción completa

Detalles Bibliográficos
Autores principales: Abraham, Bamisaye Fisayo, Olarewaju, Sulyman Abdulhakeem, Ronke, Abegunde, Oladipo, Ajani Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Journal of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684376/
https://www.ncbi.nlm.nih.gov/pubmed/29184263
_version_ 1783278465748828160
author Abraham, Bamisaye Fisayo
Olarewaju, Sulyman Abdulhakeem
Ronke, Abegunde
Oladipo, Ajani Emmanuel
author_facet Abraham, Bamisaye Fisayo
Olarewaju, Sulyman Abdulhakeem
Ronke, Abegunde
Oladipo, Ajani Emmanuel
author_sort Abraham, Bamisaye Fisayo
collection PubMed
description BACKGROUND: Diabetes mellitus is considered one of the 5 principal causes of death in the world and is recognized as a global public health issue because of its multifactorial facets affecting essential biochemical processes in the body. This study investigated the antidiabetic and antidyslipidemic activities of the aqueous extract of Cochlospermum planchonii (C. planchonii) leaves in streptozotocin (STZ)-induced diabetic rats. METHODS: Thirty adult female rats (Rattus norvegicus) weighing 153±3.41g were randomized into 6 groups of 5 animals each. STZ-induced diabetic rats were orally administered 50, 100, and 200 mg/kg body weight of the extract, respectively, once a day, and their blood glucose levels as well as variations of diabetes-associated biomarkers including alpha amylase, glucose-6-phosphate dehydrogenase (G6PDH), and lipid profile by the extract were monitored for 21 days. The results were expressed as means±SEMs and compared with repeated measures using SPSS, Data Editor, version 16.0. RESULTS: The aqueous extract of C. planchonii leaves significantly reduced the blood glucose level in a dose-dependent manner, with the highest dose producing a 74.52% reduction after 21 days of administration, which compared significantly (P<0.01) with the control and metformin-treated groups. Similarly, STZ-induced diabetic mediated alterations in the serum lipids were significantly (P<0.01) restored by the extract. In addition, the aqueous extract of C. planchonii leaves significantly attenuated the decrease in the activity of G6PDH and the increase in the activity of α-AMY in the liver of the STZ-induced diabetic rats. CONCLUSIONS: Overall, the aqueous extract of C. planchonii leaves could be used to manage diabetes and other related complications.
format Online
Article
Text
id pubmed-5684376
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Iranian Journal of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-56843762017-11-28 Antidiabetic and Antidyslipidemic Activities of the Aqueous Extract of Cochlospermum planchonii Leaves in Streptozotocin-Induced Diabetic Rats Abraham, Bamisaye Fisayo Olarewaju, Sulyman Abdulhakeem Ronke, Abegunde Oladipo, Ajani Emmanuel Iran J Med Sci Original Article BACKGROUND: Diabetes mellitus is considered one of the 5 principal causes of death in the world and is recognized as a global public health issue because of its multifactorial facets affecting essential biochemical processes in the body. This study investigated the antidiabetic and antidyslipidemic activities of the aqueous extract of Cochlospermum planchonii (C. planchonii) leaves in streptozotocin (STZ)-induced diabetic rats. METHODS: Thirty adult female rats (Rattus norvegicus) weighing 153±3.41g were randomized into 6 groups of 5 animals each. STZ-induced diabetic rats were orally administered 50, 100, and 200 mg/kg body weight of the extract, respectively, once a day, and their blood glucose levels as well as variations of diabetes-associated biomarkers including alpha amylase, glucose-6-phosphate dehydrogenase (G6PDH), and lipid profile by the extract were monitored for 21 days. The results were expressed as means±SEMs and compared with repeated measures using SPSS, Data Editor, version 16.0. RESULTS: The aqueous extract of C. planchonii leaves significantly reduced the blood glucose level in a dose-dependent manner, with the highest dose producing a 74.52% reduction after 21 days of administration, which compared significantly (P<0.01) with the control and metformin-treated groups. Similarly, STZ-induced diabetic mediated alterations in the serum lipids were significantly (P<0.01) restored by the extract. In addition, the aqueous extract of C. planchonii leaves significantly attenuated the decrease in the activity of G6PDH and the increase in the activity of α-AMY in the liver of the STZ-induced diabetic rats. CONCLUSIONS: Overall, the aqueous extract of C. planchonii leaves could be used to manage diabetes and other related complications. Iranian Journal of Medical Sciences 2017-11 /pmc/articles/PMC5684376/ /pubmed/29184263 Text en Copyright: © Iranian Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Abraham, Bamisaye Fisayo
Olarewaju, Sulyman Abdulhakeem
Ronke, Abegunde
Oladipo, Ajani Emmanuel
Antidiabetic and Antidyslipidemic Activities of the Aqueous Extract of Cochlospermum planchonii Leaves in Streptozotocin-Induced Diabetic Rats
title Antidiabetic and Antidyslipidemic Activities of the Aqueous Extract of Cochlospermum planchonii Leaves in Streptozotocin-Induced Diabetic Rats
title_full Antidiabetic and Antidyslipidemic Activities of the Aqueous Extract of Cochlospermum planchonii Leaves in Streptozotocin-Induced Diabetic Rats
title_fullStr Antidiabetic and Antidyslipidemic Activities of the Aqueous Extract of Cochlospermum planchonii Leaves in Streptozotocin-Induced Diabetic Rats
title_full_unstemmed Antidiabetic and Antidyslipidemic Activities of the Aqueous Extract of Cochlospermum planchonii Leaves in Streptozotocin-Induced Diabetic Rats
title_short Antidiabetic and Antidyslipidemic Activities of the Aqueous Extract of Cochlospermum planchonii Leaves in Streptozotocin-Induced Diabetic Rats
title_sort antidiabetic and antidyslipidemic activities of the aqueous extract of cochlospermum planchonii leaves in streptozotocin-induced diabetic rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684376/
https://www.ncbi.nlm.nih.gov/pubmed/29184263
work_keys_str_mv AT abrahambamisayefisayo antidiabeticandantidyslipidemicactivitiesoftheaqueousextractofcochlospermumplanchoniileavesinstreptozotocininduceddiabeticrats
AT olarewajusulymanabdulhakeem antidiabeticandantidyslipidemicactivitiesoftheaqueousextractofcochlospermumplanchoniileavesinstreptozotocininduceddiabeticrats
AT ronkeabegunde antidiabeticandantidyslipidemicactivitiesoftheaqueousextractofcochlospermumplanchoniileavesinstreptozotocininduceddiabeticrats
AT oladipoajaniemmanuel antidiabeticandantidyslipidemicactivitiesoftheaqueousextractofcochlospermumplanchoniileavesinstreptozotocininduceddiabeticrats