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Insertion of the Type-I IFN Decoy Receptor B18R in a miRNA-Tagged Semliki Forest Virus Improves Oncolytic Capacity but Results in Neurotoxicity

Oncolytic Semliki Forest virus (SFV) has been suggested as a potential candidate for the treatment of glioblastoma and neuroblastoma. However, the oncolytic capacity of SFV is restricted by the anti-viral type-I interferon (IFN) response. The aim of this study was to increase the oncolytic capacity...

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Detalles Bibliográficos
Autores principales:	Sarén, Tina, Ramachandran, Mohanraj, Martikainen, Miika, Yu, Di
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5684435/ https://www.ncbi.nlm.nih.gov/pubmed/29159280 http://dx.doi.org/10.1016/j.omto.2017.10.001

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